| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent neutral amino acid transporter B(0)AT2 |
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| Ligand | BDBM50031240 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1432515 (CHEMBL3386947) |
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| IC50 | 3400±n/a nM |
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| Citation |  Cuboni, S; Devigny, C; Hoogeland, B; Strasser, A; Pomplun, S; Hauger, B; Höfner, G; Wanner, KT; Eder, M; Buschauer, A; Holsboer, F; Hausch, F Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. J Med Chem57:9473-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent neutral amino acid transporter B(0)AT2 |
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| Name: | Sodium-dependent neutral amino acid transporter B(0)AT2 |
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| Synonyms: | B0AT2 | B0AT2 | NTT73 | S6A15_HUMAN | SBAT1 | SLC6A15 | Sodium- and chloride-dependent neurotransmitter transporter NTT73 | Sodium-coupled branched-chain amino-acid transporter 1 | Sodium-dependent neutral amino acid transporter B(0)AT2 | Solute carrier family 6 member 15 | Transporter v7-3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 81820.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109513 |
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| Residue: | 730 |
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| Sequence: | MPKNSKVVKRELDDDVTESVKDLLSNEDAADDAFKTSELIVDGQEEKDTDVEEGSEVEDE
RPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLMVIGIPLFFLELS
VGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWSLFYFSQSFQQPLPWD
QCPLVKNASHTFVEPECEQSSATTYYWYREALNISSSISESGGLNWKMTICLLAAWVMVC
LAMIKGIQSSGKIIYFSSLFPYVVLICFLIRAFLLNGSIDGIRHMFTPKLEIMLEPKVWR
EAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKA
NVINEKCITQNSETIMKFLKMGNISQDIIPHHINLSTVTAEDYHLVYDIIQKVKEEEFPA
LHLNSCKIEEELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLVNLGLGSMFGTIE
GIVTPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILE
NIAVCFVYGIDKFMEDLKDMLGFAPSRYYYYMWKYISPLMLLSLLIASVVNMGLSPPGYN
AWIEDKASEEFLSYPTWGLVVCVSLVVFAILPVPVVFIVRRFNLIDDSSGNLASVTYKRG
RVLKEPVNLEGDDTSLIHGKIPSEMPSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMAD
IMPDMPESDL
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| BDBM50031240 |
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| n/a |
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| Name | BDBM50031240 |
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| Synonyms: | CHEMBL3357043 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27ClN2O |
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| Mol. Mass. | 394.937 |
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| SMILES | [#6]-[#6]-[#6]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 |
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| Structure | 
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