| Reaction Details |
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 | Report a problem with these data |
| Target | Poly(ADP-ribose) glycohydrolase |
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| Ligand | BDBM50052839 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1458454 (CHEMBL3370340) |
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| IC50 | 2800±n/a nM |
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| Citation |  Islam, R; Koizumi, F; Kodera, Y; Inoue, K; Okawara, T; Masutani, M Design and synthesis of phenolic hydrazide hydrazones as potent poly(ADP-ribose) glycohydrolase (PARG) inhibitors. Bioorg Med Chem Lett24:3802-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly(ADP-ribose) glycohydrolase |
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| Name: | Poly(ADP-ribose) glycohydrolase |
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| Synonyms: | PARG_RAT | Parg | Poly(ADP-ribose) glycohydrolase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109006.89 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_109458 |
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| Residue: | 972 |
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| Sequence: | MSAGPGCEPCTKRPRWGAAGTSAPTASDSRSFPGRQKRVLDPKDAPVQFRVPPSSSACVS
GRAGPHRGSVTSFVFKQKPITTWMDTKGPKTAESESKENNNTRTDPMMSSVQKDNFYPHK
VEKLGNVPQLNLDKSPTEKSTPYLNQQQTAGVCKWHSAGERAEQLSASEPSAVTQAPKQL
SNANIDQSPPTDGHSDTDHEEDRDNQQFLTPVKLANAKQTVGDGQARSNCKCSASCQCGQ
DCAGCQREEADVIPESPLSDVGAEDIGTGSKNDNKLTGQESGLGDSPPFEKESEPESPMD
VDNSKTSCQDSEADEEASPVFDEQDDQDDRSSQTANKLSSRQAREVDGDLRKRYLTKGSE
IRLHFQFEGGSNAGTSDLNAKPSGNSSSLNVDGRSSKQHGKRDSKITDHFVRIPKSEDKR
KEQCEVRHQRAERKIPKYVPPNLPPDKKWLGTPIEEMRKMPRCGVRLPLLRPSASHTVTV
RVDLLRAGEVPKPFPTHYKDLWDNKHVKMPCSEQNLYPVEDENGERTAGSRWELIQTALL
NKFTRPQNLKDAILKYNVAYSKKWDFTALVDFWDKVLEEAEAQHLYQSILPDMVKIALCL
PNICTQPIPLLKQKMNHSVTMSQEQIASLLANAFFCTFPRRNAKMKSEYSSYPDINFNRL
FEGRSSRKPEKLKTLFCYFRRVTEKKPTGLVTFTRQSLEDFPEWERCDKPLTRLHVTYEG
TIEGNGRGMLQVDFANRFVGGGVTGAGLVQEEIRFLINPELIVSRLFTEVLDHNECLIIT
GTEQYSEYTGYAETYRWARSHEDGSEKDDWQRCCTEIVAIDALHFRRYLDQFVPEKVRRE
LNKAYCGFLRPGVPPENLSAVATGNWGCGAFGGDARLKALIQLLAAAAAERDVVYFTFGD
SELMRDIYSMHTFLTERKLNVGKVYRLLLRYYREECRDCSSPGPDTKLYPFIYHAAESSA
ETSDQPGQRTGT
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| BDBM50052839 |
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| n/a |
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| Name | BDBM50052839 |
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| Synonyms: | CHEMBL3318747 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14N4O8 |
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| Mol. Mass. | 390.3044 |
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| SMILES | Oc1cc(\C=N\NC(=O)C(=O)N\N=C\c2cc(O)c(O)c(O)c2)cc(O)c1O |
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| Structure | 
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