Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM50058214 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1453284 (CHEMBL3366233) |
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Ki | 1517±n/a nM |
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Citation | Kim, Y; Tae, J; Lee, K; Rhim, H; Choo, IH; Cho, H; Park, WK; Keum, G; Choo, H Novel N-biphenyl-2-ylmethyl 2-methoxyphenylpiperazinylalkanamides as 5-HT7R antagonists for the treatment of depression. Bioorg Med Chem22:4587-96 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM50058214 |
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n/a |
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Name | BDBM50058214 |
Synonyms: | CHEMBL3326982 |
Type | Small organic molecule |
Emp. Form. | C29H34ClN3O2 |
Mol. Mass. | 492.052 |
SMILES | COc1ccccc1N1CCN(CCCCC(=O)NCc2ccccc2-c2ccccc2Cl)CC1 |
Structure |
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