| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
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| Ligand | BDBM50075325 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1473763 (CHEMBL3418280) |
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| IC50 | 40±n/a nM |
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| Citation |  Mehra, R; Sharma, R; Khan, IA; Nargotra, A Identification and optimization of Escherichia coli GlmU inhibitors: an in silico approach with validation thereof. Eur J Med Chem92:78-90 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional protein GlmU |
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| Name: | Bifunctional protein GlmU |
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| Synonyms: | Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA |
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| Type: | Enzyme |
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| Mol. Mass.: | 49189.50 |
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| Organism: | Escherichia coli |
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| Description: | P0ACC7 |
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| Residue: | 456 |
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| Sequence: | MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD
LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA
KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM
KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ
SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK
AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT
IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
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| BDBM50075325 |
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| n/a |
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| Name | BDBM50075325 |
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| Synonyms: | CHEMBL2207599 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N2O7S |
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| Mol. Mass. | 484.522 |
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| SMILES | COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N(c1ccccc1)c1ccccc1 |
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| Structure | 
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