Reaction Details |
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Target | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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Ligand | BDBM50091138 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1500151 (CHEMBL3584585) |
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IC50 | 38±n/a nM |
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Citation | Wong, IL; Wang, BC; Yuan, J; Duan, LX; Liu, Z; Liu, T; Li, XM; Hu, X; Zhang, XY; Jiang, T; Wan, SB; Chow, LM Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives. J Med Chem58:4529-49 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Broad substrate specificity ATP-binding cassette transporter ABCG2 |
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Name: | Broad substrate specificity ATP-binding cassette transporter ABCG2 |
Synonyms: | ABCG2 | ABCG2_HUMAN | ABCP | ATP-Binding Cassette Transporter ABCG2 | ATP-binding cassette sub-family G member 2 | ATP-binding cassette transporter (ABCG2) | ATP-binding cassette, sub-family G, member 2 | BCRP | BCRP1 | Breast cancer resistance protein | CDw338 | MXR | Mitoxantrone resistance-associated protein | Placenta-specific ATP-binding cassette transporter | Urate exporter |
Type: | Multi-pass membrane protein; monomer or homodimer; disulfide-linked |
Mol. Mass.: | 72329.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9UNQ0 |
Residue: | 655 |
Sequence: | MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICYRVKLKSGFLPCRKPVE
KEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGLSGDVLINGAPRPANFKCN
SGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNERINRVIQELGLDKVADSKVGT
QFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIF
SIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGYFESAGYHCEAYNNPADFFLDIING
DSTAVALNREEDFKATEIIEPSKQDKPLIEKLAEIYVNSSFYKETKAELHQLSGGEKKKK
ITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQASIAQIIVTVVLGLVIGAIYFGLKNDS
TGIQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFLGKLLSDLLP
MRMLPSIIFTCIVYFMLGLKPKADAFFVMMFTLMMVAYSASSMALAIAAGQSVVSVATLL
MTICFVFMMIFSGLLVNLTTIASWLSWLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGN
NPCNYATCTGEEYLVKQGIDLSPWGLWKNHVALACMIVIFLTIAYLKLLFLKKYS
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BDBM50091138 |
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n/a |
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Name | BDBM50091138 |
Synonyms: | CHEMBL3582168 |
Type | Small organic molecule |
Emp. Form. | C37H38FNO12 |
Mol. Mass. | 707.6955 |
SMILES | COc1cc(OC)c2C[C@H](OC(=O)c3ccc(F)c(NC(=O)c4cc(OC)c(OC)c(OC)c4)c3)[C@H](Oc2c1)c1cc(OC)c(OC)c(OC)c1 |r| |
Structure |
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