Ki Summary

Reaction Details

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Target

Tyrosine-protein phosphatase non-receptor type 1

Ligand

BDBM50093524

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1501268 (CHEMBL3587977)

10400±n/a nM

Citation

Nguyen, PH; Ji, DJ; Han, YR; Choi, JS; Rhyu, DY; Min, BS; Woo, MH Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects. Bioorg Med Chem23:3730-7 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein phosphatase non-receptor type 1

Name:

Tyrosine-protein phosphatase non-receptor type 1

Synonyms:

Type:

Protein phosphatase

Mol. Mass.:

49963.76

Organism:

Homo sapiens (Human)

Description:

Human recombinant GST-fusion PTP1B (1-435).

Residue:

435

Sequence:

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT

BDBM50093524

n/a

Name

BDBM50093524

Synonyms:

CHEMBL3585680

Type

Small organic molecule

Emp. Form.

C30H20O10

Mol. Mass.

540.4738

SMILES

Oc1ccc(cc1)-c1cc(=O)c2ccc(O)c(-c3cc([C@@H]4CC(=O)c5c(O)cc(O)cc5O4)c(O)cc3O)c2o1 |r,wD:20.20,(1.56,-5.97,;2.63,-5.36,;3.96,-6.14,;5.3,-5.38,;5.31,-3.84,;3.98,-3.06,;2.64,-3.82,;6.65,-3.07,;7.97,-3.85,;9.31,-3.09,;10.37,-3.71,;9.32,-1.55,;10.65,-.79,;10.67,.76,;9.34,1.54,;9.34,2.77,;8,.76,;6.66,1.53,;5.33,.77,;4,1.54,;2.66,.77,;2.66,-.77,;1.33,-1.54,;1.33,-2.77,;,-.77,;-1.33,-1.54,;-1.33,-2.77,;-2.68,-.77,;-2.68,.77,;-3.75,1.39,;-1.33,1.54,;,.77,;1.33,1.54,;4,3.08,;2.93,3.7,;5.33,3.85,;6.67,3.07,;7.73,3.69,;7.99,-.78,;6.65,-1.54,)|

Structure