| Reaction Details |
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 | Report a problem with these data |
| Target | Dipeptidyl peptidase 8 |
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| Ligand | BDBM50096874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1499215 (CHEMBL3582604) |
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| IC50 | >10000±n/a nM |
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| Citation |  Jiang, T; Zhou, Y; Chen, Z; Sun, P; Zhu, J; Zhang, Q; Wang, Z; Shao, Q; Jiang, X; Li, B; Chen, K; Jiang, H; Wang, H; Zhu, W; Shen, J Design, Synthesis, and Pharmacological Evaluation of Fusedß-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors. ACS Med Chem Lett6:602-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dipeptidyl peptidase 8 |
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| Name: | Dipeptidyl peptidase 8 |
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| Synonyms: | DPP8 | DPP8_HUMAN | DPRP-1 | DPRP1 | Dipeptidyl peptidase 8 (DPP-8) | Dipeptidyl peptidase 8 (DPP8) | Dipeptidyl peptidase 8/9 | Dipeptidyl peptidase IV-related protein 1 | Dipeptidyl peptidase VIII | Dipeptidyl peptidase VIII (DDP-VIII) | Prolyl dipeptidase DPP8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 103342.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q6V1X1 |
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| Residue: | 898 |
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| Sequence: | MWKRSEQMKIKSGKCNMAAAMETEQLGVEIFETADCEENIESQDRPKLEPFYVERYSWSQ
LKKLLADTRKYHGYMMAKAPHDFMFVKRNDPDGPHSDRIYYLAMSGENRENTLFYSEIPK
TINRAAVLMLSWKPLLDLFQATLDYGMYSREEELLRERKRIGTVGIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAFIHSNDIWISN
IVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILR
ILYEENDESEVEIIHVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVI
DKELIQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIPVEDDVM
ERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLY
KITSILKESKYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVYF
EGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLY
KLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGK
KYPTVLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKFEGAFKY
KMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAP
VTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFAH
TSILLSFLVRAGKPYDLQIYPQERHSIRVPESGEHYELHLLHYLQENLGSRIAALKVI
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| BDBM50096874 |
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| n/a |
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| Name | BDBM50096874 |
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| Synonyms: | CHEMBL3580775 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F5N5O |
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| Mol. Mass. | 415.3604 |
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| SMILES | [H][C@@]1(CCc2cc(F)c(F)cc12)[C@@H](N)CC(=O)N1CCn2c(C1)nnc2C(F)(F)F |r| |
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| Structure | 
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