| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C theta type |
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| Ligand | BDBM50097498 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1500450 (CHEMBL3587275) |
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| IC50 | 0.140000±n/a nM |
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| Citation |  Kunikawa, S; Tanaka, A; Mukoyoshi, K; Nagashima, S; Tominaga, H; Chida, N; Tasaki, M; Shirai, F Optimization of 2,4-diamino-5-fluoropyrimidine derivatives as protein kinase C theta inhibitors with mitigated time-dependent drug-drug interactions and P-gp liability. Bioorg Med Chem23:3269-77 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C theta type |
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| Name: | Protein kinase C theta type |
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| Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 81878.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
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| Residue: | 706 |
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| Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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| BDBM50097498 |
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| n/a |
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| Name | BDBM50097498 |
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| Synonyms: | CHEMBL3586039 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H28FN9O |
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| Mol. Mass. | 441.5051 |
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| SMILES | CCN1CCC[C@@H](CNc2nc(Nc3cc(OC)cc(c3)-n3nnnc3C)ncc2F)C1 |r| |
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| Structure | 
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