Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | von Hippel-Lindau disease tumor suppressor |
---|
Ligand | BDBM50099052 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1459715 (CHEMBL3370433) |
---|
Kd | 2320±n/a nM |
---|
Citation | Galdeano, C; Gadd, MS; Soares, P; Scaffidi, S; Van Molle, I; Birced, I; Hewitt, S; Dias, DM; Ciulli, A Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von Hippel-Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities. J Med Chem57:8657-63 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
von Hippel-Lindau disease tumor suppressor |
---|
Name: | von Hippel-Lindau disease tumor suppressor |
Synonyms: | Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL |
Type: | Protein |
Mol. Mass.: | 24136.87 |
Organism: | Homo sapiens (Human) |
Description: | P40337 |
Residue: | 213 |
Sequence: | MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
|
|
|
BDBM50099052 |
---|
n/a |
---|
Name | BDBM50099052 |
Synonyms: | CHEMBL3344150 |
Type | Small organic molecule |
Emp. Form. | C34H41N5O5S |
Mol. Mass. | 631.785 |
SMILES | CC(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r| |
Structure |
|