| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
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| Ligand | BDBM50102676 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443091 (CHEMBL3380797) |
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| IC50 | 1700±n/a nM |
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| Citation |  Doig, P; Boriack-Sjodin, PA; Dumas, J; Hu, J; Itoh, K; Johnson, K; Kazmirski, S; Kinoshita, T; Kuroda, S; Sato, TO; Sugimoto, K; Tohyama, K; Aoi, H; Wakamatsu, K; Wang, H Rational design of inhibitors of the bacterial cell wall synthetic enzyme GlmU using virtual screening and lead-hopping. Bioorg Med Chem22:6256-69 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional protein GlmU |
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| Name: | Bifunctional protein GlmU |
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| Synonyms: | Bifunctional protein (GlmU) | GLMU_ECOLI | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | glmU | yieA |
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| Type: | Enzyme |
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| Mol. Mass.: | 49189.50 |
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| Organism: | Escherichia coli |
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| Description: | P0ACC7 |
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| Residue: | 456 |
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| Sequence: | MLNNAMSVVILAAGKGTRMYSDLPKVLHTLAGKAMVQHVIDAANELGAAHVHLVYGHGGD
LLKQALKDDNLNWVLQAEQLGTGHAMQQAAPFFADDEDILMLYGDVPLISVETLQRLRDA
KPQGGIGLLTVKLDDPTGYGRITRENGKVTGIVEHKDATDEQRQIQEINTGILIANGADM
KRWLAKLTNNNAQGEYYITDIIALAYQEGREIVAVHPQRLSEVEGVNNRLQLSRLERVYQ
SEQAEKLLLAGVMLRDPARFDLRGTLTHGRDVEIDTNVIIEGNVTLGHRVKIGTGCVIKN
SVIGDDCEISPYTVVEDANLAAACTIGPFARLRPGAELLEGAHVGNFVEMKKARLGKGSK
AGHLTYLGDAEIGDNVNIGAGTITCNYDGANKFKTIIGDDVFVGSDTQLVAPVTVGKGAT
IAAGTTVTRNVGENALAISRVPQTQKEGWRRPVKKK
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| BDBM50102676 |
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| n/a |
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| Name | BDBM50102676 |
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| Synonyms: | CHEMBL3343055 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21N5O5 |
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| Mol. Mass. | 459.454 |
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| SMILES | COc1cc(cc(c1)C(=O)Nc1ccc(NC(=O)c2ccccn2)cc1)N1CCC(=O)NC1=O |
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| Structure | 
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