| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50109026 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1508581 (CHEMBL3602664) |
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| EC50 | 980±n/a nM |
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| Citation |  Meena, CL; Thakur, A; Nandekar, PP; Sangamwar, AT; Sharma, SS; Jain, R Synthesis of CNS active thyrotropin-releasing hormone (TRH)-like peptides: Biological evaluation and effect on cognitive impairment induced by cerebral ischemia in mice. Bioorg Med Chem23:5641-53 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44568.52 |
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| Organism: | MOUSE |
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| Description: | thyrotropin-releasing hormone R1 TRHR MOUSE::P21761 |
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| Residue: | 393 |
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| Sequence: | MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIH
QNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKES
DRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
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| BDBM50109026 |
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| n/a |
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| Name | BDBM50109026 |
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| Synonyms: | CHEMBL3600445 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23I2N7O3 |
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| Mol. Mass. | 699.2828 |
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| SMILES | NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1nc(I)n(Cc2ccccc2)c1I)NC(=O)c1cnccn1 |r| |
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| Structure | 
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