| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin I |
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| Ligand | BDBM50139141 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1553799 (CHEMBL3767014) |
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| IC50 | 2400±n/a nM |
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| Citation |  Rasina, D; Otikovs, M; Leitans, J; Recacha, R; Borysov, OV; Kanepe-Lapsa, I; Domraceva, I; Pantelejevs, T; Tars, K; Blackman, MJ; Jaudzems, K; Jirgensons, A Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV. J Med Chem59:374-87 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin I |
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| Name: | Plasmepsin I |
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| Synonyms: | PFAPG | PLM1_PLAFX | PMI | Plasmepsin 1 | Plasmepsin-1 precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 51463.30 |
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| Organism: | Plasmodium falciparum |
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| Description: | n/a |
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| Residue: | 452 |
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| Sequence: | MALSIKEDFSSAFAKNESAVNSSTFNNNMKTWKIQKRFQILYVFFFLLITGALFYYLIDN
VLFPKNKKINEIMNTSKHVIIGFSIENSHDRIMKTVKQHRLKNYIKESLKFFKTGLTQKP
HLGNAGDSVTLNDVANVMYYGEAQIGDNKQKFAFIFDTGSANLWVPSAQCNTIGCKTKNL
YDSNKSKTYEKDGTKVEMNYVSGTVSGFFSKDIVTIANLSFPYKFIEVTDTNGFEPAYTL
GQFDGIVGLGWKDLSIGSVDPVVVELKNQNKIEQAVFTFYLPFDDKHKGYLTIGGIEDRF
YEGQLTYEKLNHDLYWQVDLDLHFGNLTVEKATAIVDSGTSSITAPTEFLNKFFEGLDVV
KIPFLPLYITTCNNPKLPTLEFRSATNVYTLEPEYYLQQIFDFGISLCMVSIIPVDLNKN
TFILGDPFMRKYFTVFDYDNHTVGFALAKKKL
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| BDBM50139141 |
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| n/a |
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| Name | BDBM50139141 |
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| Synonyms: | CHEMBL3764837 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H23N3O2 |
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| Mol. Mass. | 397.469 |
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| SMILES | Nc1nc2cc(ccc2c(=O)n1C[C@@H]1CC[C@H](O1)c1ccccc1)-c1ccccc1 |r| |
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| Structure | 
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