Ki Summary

Reaction Details

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Target

Calmodulin-domain protein kinase 1

Ligand

BDBM50148729

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1557115 (CHEMBL3773067)

IC50

39±n/a nM

Citation

Huang, W; Ojo, KK; Zhang, Z; Rivas, K; Vidadala, RS; Scheele, S; DeRocher, AE; Choi, R; Hulverson, MA; Barrett, LK; Bruzual, I; Siddaramaiah, LK; Kerchner, KM; Kurnick, MD; Freiberg, GM; Kempf, D; Hol, WG; Merritt, EA; Neckermann, G; de Hostos, EL; Isoherranen, N; Maly, DJ; Parsons, M; Doggett, JS; Van Voorhis, WC; Fan, E SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1. ACS Med Chem Lett6:1184-1189 (2015) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Calmodulin-domain protein kinase 1

Name:

Calmodulin-domain protein kinase 1

Synonyms:

Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57248.42

Organism:

Toxoplasma gondii

Description:

n/a

Residue:

507

Sequence:

MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN

BDBM50148729

n/a

Name

BDBM50148729

Synonyms:

CHEMBL3770923 | US9518026, Example 66 | US9956214, Compound 1565

Type

Small organic molecule

Emp. Form.

C18H18F3N5O2

Mol. Mass.

393.363

SMILES

CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC(F)(F)F)ccc2c1

Structure