| Reaction Details |
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 | Report a problem with these data |
| Target | Thyrotropin-releasing hormone receptor |
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| Ligand | BDBM50158418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1564319 (CHEMBL3784640) |
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| IC50 | 170±n/a nM |
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| Citation |  Meena, CL; Thakur, A; Nandekar, PP; Sharma, SS; Sangamwar, AT; Jain, R Synthesis and biology of ring-modified l-Histidine containing thyrotropin-releasing hormone (TRH) analogues. Eur J Med Chem111:72-83 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thyrotropin-releasing hormone receptor |
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| Name: | Thyrotropin-releasing hormone receptor |
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| Synonyms: | TRH-R | TRHR_MOUSE | Thyroliberin receptor | Trhr | thyrotropin-releasing hormone R1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 44568.52 |
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| Organism: | MOUSE |
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| Description: | thyrotropin-releasing hormone R1 TRHR MOUSE::P21761 |
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| Residue: | 393 |
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| Sequence: | MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPT
NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT
IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCG
YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIH
QNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW
FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKES
DRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
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| BDBM50158418 |
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| n/a |
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| Name | BDBM50158418 |
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| Synonyms: | CHEMBL3780746 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23BrN6O4 |
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| Mol. Mass. | 455.306 |
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| SMILES | Cn1cc(C[C@H](NC(=O)[C@@H]2CCC(=O)N2)C(=O)N2CCC[C@H]2C(N)=O)nc1Br |r| |
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| Structure | 
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