| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Ligand | BDBM50159508 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1569467 |
|---|
| IC50 | 3200±n/a nM |
|---|
| Citation |  Harris, PA; King, BW; Bandyopadhyay, D; Berger, SB; Campobasso, N; Capriotti, CA; Cox, JA; Dare, L; Dong, X; Finger, JN; Grady, LC; Hoffman, SJ; Jeong, JU; Kang, J; Kasparcova, V; Lakdawala, AS; Lehr, R; McNulty, DE; Nagilla, R; Ouellette, MT; Pao, CS; Rendina, AR; Schaeffer, MC; Summerfield, JD; Swift, BA; Totoritis, RD; Ward, P; Zhang, A; Zhang, D; Marquis, RW; Bertin, J; Gough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem59:2163-78 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Name: | Receptor-interacting serine/threonine-protein kinase 1 |
|---|
| Synonyms: | Cell death protein RIP | RIP-1 | RIPK1_MOUSE | Receptor-interacting protein 1 | Receptor-interacting serine/threonine-protein kinase 1 | Rinp | Rinp | Rip | Ripk1 | Serine/threonine-protein kinase RIP |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 74852.62 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_116773 |
|---|
| Residue: | 656 |
|---|
| Sequence: | MQPDMSLDNIKMASSDLLEKTDLDSGGFGKVSLCYHRSHGFVILKKVYTGPNRAEYNEVL
LEEGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIV
EAIEGMCYLHDKGVIHKDLKPENILVDRDFHIKIADLGVASFKTWSKLTKEKDNKQKEVS
STTKKNNGGTLYYMAPEHLNDINAKPTEKSDVYSFGIVLWAIFAKKEPYENVICTEQFVI
CIKSGNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEE
DVASLKKEYPDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLQMGPVEESWFSS
SPEYPQDENDRSVQAKLQEEASYHAFGIFAEKQTKPQPRQNEAYNREEERKRRVSHDPFA
QQRARENIKSAGARGHSDPSTTSRGIAVQQLSWPATQTVWNNGLYNQHGFGTTGTGVWYP
PNLSQMYSTYKTPVPETNIPGSTPTMPYFSGPVADDLIKYTIFNSSGIQIGNHNYMDVGL
NSQPPNNTCKEESTSRHQAIFDNTTSLTDEHLNPIRENLGRQWKNCARKLGFTESQIDEI
DHDYERDGLKEKVYQMLQKWLMREGTKGATVGKLAQALHQCCRIDLLNHLIRASQS
|
|
|
|---|
| BDBM50159508 |
|---|
| n/a |
|---|
| Name | BDBM50159508 |
|---|
| Synonyms: | CHEMBL3786078 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20N4O3 |
|---|
| Mol. Mass. | 376.4085 |
|---|
| SMILES | CN1c2ccccc2NC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
