Reaction Details |
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Target | Receptor-interacting serine/threonine-protein kinase 1 |
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Ligand | BDBM50159507 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1569443 (CHEMBL3789105) |
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IC50 | 1.6±n/a nM |
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Citation | Harris, PA; King, BW; Bandyopadhyay, D; Berger, SB; Campobasso, N; Capriotti, CA; Cox, JA; Dare, L; Dong, X; Finger, JN; Grady, LC; Hoffman, SJ; Jeong, JU; Kang, J; Kasparcova, V; Lakdawala, AS; Lehr, R; McNulty, DE; Nagilla, R; Ouellette, MT; Pao, CS; Rendina, AR; Schaeffer, MC; Summerfield, JD; Swift, BA; Totoritis, RD; Ward, P; Zhang, A; Zhang, D; Marquis, RW; Bertin, J; Gough, PJ DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors. J Med Chem59:2163-78 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Receptor-interacting serine/threonine-protein kinase 1 |
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Name: | Receptor-interacting serine/threonine-protein kinase 1 |
Synonyms: | Cell death protein RIP | RIP | RIP-1 | RIP1 | RIPK1 | RIPK1_HUMAN | Receptor-interacting protein 1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 75926.99 |
Organism: | Homo sapiens (Human) |
Description: | Q13546 |
Residue: | 671 |
Sequence: | MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEAL
LEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIIL
EIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVD
GTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMC
IKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEED
VKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFA
PSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPF
AQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLD
PGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQ
IGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKN
CARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRID
LLSSLIYVSQN
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BDBM50159507 |
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n/a |
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Name | BDBM50159507 |
Synonyms: | CHEMBL3785703 |
Type | Small organic molecule |
Emp. Form. | C21H19N3O4 |
Mol. Mass. | 377.3933 |
SMILES | CN1c2ccccc2OC[C@H](NC(=O)c2cc(Cc3ccccc3)on2)C1=O |r| |
Structure |
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