| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/nucleoside cotransporter 2 |
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| Ligand | BDBM50172394 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1579907 (CHEMBL3813163) |
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| IC50 | 60000±n/a nM |
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| Citation |  Tatani, K; Hiratochi, M; Kikuchi, N; Kuramochi, Y; Watanabe, S; Yamauchi, Y; Itoh, F; Isaji, M; Shuto, S Identification of Adenine and Benzimidazole Nucleosides as Potent Human Concentrative Nucleoside Transporter 2 Inhibitors: Potential Treatment for Hyperuricemia and Gout. J Med Chem59:3719-31 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/nucleoside cotransporter 2 |
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| Name: | Sodium/nucleoside cotransporter 2 |
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| Synonyms: | CNT 2 | Cnt2 | Cnt2 | Concentrative nucleoside transporter 2 | Na(+)/nucleoside cotransporter 2 | S28A2_RAT | Slc28a2 | Sodium-coupled nucleoside transporter 2 | Sodium/nucleoside cotransporter 2 | Sodium/purine nucleoside cotransporter | Solute carrier family 28 member 2 | Spnt | rCNT2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 72627.77 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_103618 |
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| Residue: | 659 |
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| Sequence: | MAKSEGRKSASQDTSENGMENPGLELMEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRI
LQPFTKARSFYQRHAGLFKKILLGLLCLAYAAYLLAACILNFRRALALFVITCLVIFILA
CHFLKKFFAKKSIRCLKPLKNTRLRLWLKRVFMGAAVVGLILWLALDTAQRPEQLISFAG
ICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAY
TVEGSSFVFGDTLVQSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTT
AAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDA
SSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIAL
VANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPL
VAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANL
TSIGITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGILYVPRGAETDCVSFL
NTNFTNRTYETYVCCRELFQSTLLNGTNMPSFSGPWQDKESSLRNLAKCCDLYTSTVCA
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| BDBM50172394 |
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| n/a |
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| Name | BDBM50172394 |
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| Synonyms: | CHEMBL3809286 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H34N6O6 |
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| Mol. Mass. | 550.6062 |
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| SMILES | Nc1ncnc2n([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c(NCc3ccc(c(OCCCCCO)c3)-c3ccccc3)nc12 |r| |
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| Structure | 
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