Found 327 hits with Last Name = 'watanabe' and Initial = 's' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058752
(CHEMBL3335630)Show SMILES COCCOCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:32:33:36:40.38.39,38:37:34:40.39.41,38:39:36.37.42:34,41:39:36:42.33.34,41:33:36:40.38.39| Show InChI InChI=1S/C41H50N4O3/c1-30-26-44(27-33-7-12-39(42-25-33)29-48-18-17-47-2)15-16-45(30)28-32-3-8-37(9-4-32)40(46)43-38-10-5-31(6-11-38)13-14-41-22-34-19-35(23-41)21-36(20-34)24-41/h3-12,25,30,34-36H,15-24,26-29H2,1-2H3,(H,43,46)/t30-,34?,35?,36?,41?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 0.470 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036542
(CHEMBL3353600)Show SMILES CC(C)(C)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C24H22ClF3N2O4S/c1-23(2,3)17-8-4-15(5-9-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-10-6-16(7-11-19)22(31)32/h4-13H,14H2,1-3H3,(H,31,32) | PDB
KEGG
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| Purchase
CHEMBL
PC cid
PC sid
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| Article
PubMed
| n/a | n/a | 0.960 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058757
(CHEMBL3335423)Show SMILES O=C(Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 |THB:10:11:14:18.16.17,16:15:12:18.17.19,16:17:14.15.20:12,19:17:14:20.11.12,19:11:14:18.16.17| Show InChI InChI=1S/C36H40N4O/c41-35(33-7-3-28(4-8-33)25-39-14-16-40(17-15-39)26-29-2-1-13-37-24-29)38-34-9-5-27(6-10-34)11-12-36-21-30-18-31(22-36)20-32(19-30)23-36/h1-10,13,24,30-32H,14-23,25-26H2,(H,38,41) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
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UniChem
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| Article
PubMed
| n/a | n/a | 0.970 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058753
(CHEMBL3335427)Show SMILES COCc1ccc(CN2CCN(Cc3ccc(cc3)C(=O)Nc3ccc(cc3)C#CC34CC5CC(CC(C5)C3)C4)[C@@H](C)C2)cn1 |r,THB:29:30:33:37.35.36,35:34:31:37.36.38,35:36:33.34.39:31,38:36:33:39.30.31,38:30:33:37.35.36| Show InChI InChI=1S/C39H46N4O2/c1-28-24-42(25-31-7-12-37(27-45-2)40-23-31)15-16-43(28)26-30-3-8-35(9-4-30)38(44)41-36-10-5-29(6-11-36)13-14-39-20-32-17-33(21-39)19-34(18-32)22-39/h3-12,23,28,32-34H,15-22,24-27H2,1-2H3,(H,41,44)/t28-,32?,33?,34?,39?/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058754
(CHEMBL3335426)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C#CC12CC3CC(CC(C3)C1)C2 |r,THB:31:32:35:39.37.38,37:36:33:39.38.40,37:38:35.36.41:33,40:38:35:41.32.33,40:32:35:39.37.38| Show InChI InChI=1S/C37H42N4O/c1-27-24-40(25-30-3-2-14-38-23-30)15-16-41(27)26-29-4-8-34(9-5-29)36(42)39-35-10-6-28(7-11-35)12-13-37-20-31-17-32(21-37)19-33(18-31)22-37/h2-11,14,23,27,31-33H,15-22,24-26H2,1H3,(H,39,42)/t27-,31?,32?,33?,37?/m0/s1 | PDB
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| CHEMBL
PC cid
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UniChem
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| Article
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| n/a | n/a | 2.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058760
(CHEMBL3335421)Show SMILES O=C(Nc1ccc(cc1)C#CC1CCCCC1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C32H36N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h4,7,10-18,23,26H,1-3,5-6,19-22,24-25H2,(H,34,37) | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058766
(CHEMBL3335415)Show SMILES C[C@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m0/s1 | PDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036544
(CHEMBL3353601)Show SMILES CC(C)(c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1)C(F)(F)F Show InChI InChI=1S/C24H19ClF6N2O4S/c1-22(2,24(29,30)31)16-7-3-14(4-8-16)13-33(20-19(25)11-17(12-32-20)23(26,27)28)38(36,37)18-9-5-15(6-10-18)21(34)35/h3-12H,13H2,1-2H3,(H,34,35) | PDB
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| Article
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559528
(CHEMBL3950588)Show SMILES CCc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559538
(CHEMBL3908950)Show SMILES CSc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220573
(1-(1-(3-chloro-4-hydroxyphenyl)-1-hydroxypropan-2-...)Show SMILES CC(C(O)c1ccc(O)c(Cl)c1)N1CCC(O)(CC1)c1ccc(F)cc1 |w:1.0,2.2| Show InChI InChI=1S/C20H23ClFNO3/c1-13(19(25)14-2-7-18(24)17(21)12-14)23-10-8-20(26,9-11-23)15-3-5-16(22)6-4-15/h2-7,12-13,19,24-26H,8-11H2,1H3 | PDB
UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058755
(CHEMBL3335425)Show SMILES Nc1ncccc1C(=O)N1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(cc2)C#CC23CC4CC(CC(C4)C2)C3)CC1 |THB:30:31:34:38.36.37,36:35:32:38.37.39,36:37:34.35.40:32,39:37:34:40.31.32,39:31:34:38.36.37| Show InChI InChI=1S/C36H39N5O2/c37-33-32(2-1-13-38-33)35(43)41-16-14-40(15-17-41)24-26-3-7-30(8-4-26)34(42)39-31-9-5-25(6-10-31)11-12-36-21-27-18-28(22-36)20-29(19-27)23-36/h1-10,13,27-29H,14-24H2,(H2,37,38)(H,39,42) | PDB
UniProtKB/SwissProt
antibodypedia
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036517
(CHEMBL3353597)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036555
(CHEMBL3353610 | US9434711, 497)Show SMILES Cc1c(sc2ccccc12)N(Cc1ccc(c(F)c1)C(F)(F)F)S(=O)(=O)c1ccc(cc1)C(O)=O Show InChI InChI=1S/C24H17F4NO4S2/c1-14-18-4-2-3-5-21(18)34-22(14)29(13-15-6-11-19(20(25)12-15)24(26,27)28)35(32,33)17-9-7-16(8-10-17)23(30)31/h2-12H,13H2,1H3,(H,30,31) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220589
(6-(1-hydroxy-2-(4-hydroxy-4-(3-(phenoxymethyl)phen...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1cccc(COc2ccccc2)c1 |w:2.2,1.0| Show InChI InChI=1S/C30H34N2O4/c1-21(29(34)24-10-12-27-23(19-24)11-13-28(33)31-27)32-16-14-30(35,15-17-32)25-7-5-6-22(18-25)20-36-26-8-3-2-4-9-26/h2-10,12,18-19,21,29,34-35H,11,13-17,20H2,1H3,(H,31,33) | PDB
UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220583
(6-(2-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1ccc(Cl)cc1 |w:2.2,1.0| Show InChI InChI=1S/C23H27ClN2O3/c1-15(22(28)17-2-8-20-16(14-17)3-9-21(27)25-20)26-12-10-23(29,11-13-26)18-4-6-19(24)7-5-18/h2,4-8,14-15,22,28-29H,3,9-13H2,1H3,(H,25,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220586
(1-[2-hydroxy-2-(6-hydroxy-biphenyl-3-yl)-1-methyl-...)Show SMILES OC(CN1CCC(O)(CC1)c1cccc(F)c1)c1ccc2NC(=O)CCc2c1 |w:1.0| Show InChI InChI=1S/C22H25FN2O3/c23-18-3-1-2-17(13-18)22(28)8-10-25(11-9-22)14-20(26)16-4-6-19-15(12-16)5-7-21(27)24-19/h1-4,6,12-13,20,26,28H,5,7-11,14H2,(H,24,27) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058762
(CHEMBL3335419)Show SMILES O=C(Nc1ccc(cc1)C#Cc1ccccc1)c1ccc(CN2CCN(Cc3cccnc3)CC2)cc1 Show InChI InChI=1S/C32H30N4O/c37-32(34-31-16-12-27(13-17-31)9-8-26-5-2-1-3-6-26)30-14-10-28(11-15-30)24-35-19-21-36(22-20-35)25-29-7-4-18-33-23-29/h1-7,10-18,23H,19-22,24-25H2,(H,34,37) | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058770
(CHEMBL3335411)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccncc4)CC3)cc2)cc1 Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-5-7-23(8-6-22)30-24(33)21-3-1-19(2-4-21)17-31-13-15-32(16-14-31)18-20-9-11-29-12-10-20/h1-12H,13-18H2,(H,30,33) | PDB
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| n/a | n/a | 7.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036545
(CHEMBL3353602)Show SMILES CC1(CC1)c1ccc(CN(c2ncc(cc2Cl)C(F)(F)F)S(=O)(=O)c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C24H20ClF3N2O4S/c1-23(10-11-23)17-6-2-15(3-7-17)14-30(21-20(25)12-18(13-29-21)24(26,27)28)35(33,34)19-8-4-16(5-9-19)22(31)32/h2-9,12-13H,10-11,14H2,1H3,(H,31,32) | PDB
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| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036517
(CHEMBL3353597)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(OC(F)(F)F)cc1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220588
(6-(1-hydroxy-2-(4-hydroxy-4-(3-methoxyphenyl)piper...)Show SMILES COc1cccc(c1)C1(O)CCN(CC1)C(C)C(O)c1ccc2NC(=O)CCc2c1 |w:17.19,15.17| Show InChI InChI=1S/C24H30N2O4/c1-16(23(28)18-6-8-21-17(14-18)7-9-22(27)25-21)26-12-10-24(29,11-13-26)19-4-3-5-20(15-19)30-2/h3-6,8,14-16,23,28-29H,7,9-13H2,1-2H3,(H,25,27) | PDB
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| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220581
(7-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)COc2c1)N1CCC(O)(CC1)c1ccc(F)cc1 |w:2.2,1.0| Show InChI InChI=1S/C22H25FN2O4/c1-14(21(27)15-2-7-18-19(12-15)29-13-20(26)24-18)25-10-8-22(28,9-11-25)16-3-5-17(23)6-4-16/h2-7,12,14,21,27-28H,8-11,13H2,1H3,(H,24,26) | PDB
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GoogleScholar
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| CHEMBL
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PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559527
(CHEMBL3907970)Show SMILES CCCc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
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| KEGG
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UniChem
| Article
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| n/a | n/a | 8.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036537
(CHEMBL3353594)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H13ClF6N2O4S/c22-17-9-15(21(26,27)28)10-29-18(17)30(11-12-1-5-14(6-2-12)20(23,24)25)35(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32) | PDB
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| n/a | n/a | 8.90 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Rattus norvegicus (Rat)) | BDBM50036554
(CHEMBL3353609)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C20H13Cl2F3N2O4S/c21-15-9-17(22)18(26-10-15)27(11-12-1-5-14(6-2-12)20(23,24)25)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at rat TRPM8 assessed as inhibition of menthol induced Ca2+ influx by cell-based assay |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025312
(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-(3-...)Show SMILES COc1cc2oc(cc(=O)c2c(O)c1OCCC(C)C)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C21H22O7/c1-11(2)6-7-27-21-18(26-3)10-17-19(20(21)25)15(24)9-16(28-17)12-4-5-13(22)14(23)8-12/h4-5,8-11,22-23,25H,6-7H2,1-3H3 | PDB
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| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220574
(6-(1-hydroxy-2-(4-hydroxy-4-p-tolylpiperidin-1-yl)...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1ccc(C)cc1 |w:2.2,1.0| Show InChI InChI=1S/C24H30N2O3/c1-16-3-7-20(8-4-16)24(29)11-13-26(14-12-24)17(2)23(28)19-5-9-21-18(15-19)6-10-22(27)25-21/h3-5,7-9,15,17,23,28-29H,6,10-14H2,1-2H3,(H,25,27) | PDB
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| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220584
(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)NCc2c1)N1CCC(O)(CC1)c1ccc(F)cc1 |w:2.2,1.0| Show InChI InChI=1S/C22H26FN3O3/c1-14(20(27)15-2-7-19-16(12-15)13-24-21(28)25-19)26-10-8-22(29,9-11-26)17-3-5-18(23)6-4-17/h2-7,12,14,20,27,29H,8-11,13H2,1H3,(H2,24,25,28) | PDB
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PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559522
(CHEMBL3960449)Show SMILES CC(C)Oc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
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antibodypedia
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| KEGG
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PC sid
UniChem
| Article
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220577
(6-(2-(4-(3-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1cccc(F)c1 |w:2.2,1.0| Show InChI InChI=1S/C23H27FN2O3/c1-15(22(28)17-5-7-20-16(13-17)6-8-21(27)25-20)26-11-9-23(29,10-12-26)18-3-2-4-19(24)14-18/h2-5,7,13-15,22,28-29H,6,8-12H2,1H3,(H,25,27) | PDB
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| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559524
(CHEMBL3923809)Show SMILES CCOc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
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antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220576
(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1ccc(F)cc1 |w:2.2,1.0| Show InChI InChI=1S/C23H27FN2O3/c1-15(22(28)17-2-8-20-16(14-17)3-9-21(27)25-20)26-12-10-23(29,11-13-26)18-4-6-19(24)7-5-18/h2,4-8,14-15,22,28-29H,3,9-13H2,1H3,(H,25,27) | PDB
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UniChem
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| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025315
(2-(3,4-Dihydroxy-phenyl)-5-hydroxy-7-methoxy-6-oct...)Show SMILES CCCCCCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C24H28O7/c1-3-4-5-6-7-8-11-30-24-21(29-2)14-20-22(23(24)28)18(27)13-19(31-20)15-9-10-16(25)17(26)12-15/h9-10,12-14,25-26,28H,3-8,11H2,1-2H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025322
(6-Decyloxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-me...)Show SMILES CCCCCCCCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C26H32O7/c1-3-4-5-6-7-8-9-10-13-32-26-23(31-2)16-22-24(25(26)30)20(29)15-21(33-22)17-11-12-18(27)19(28)14-17/h11-12,14-16,27-28,30H,3-10,13H2,1-2H3 | PDB
MMDB
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UniProtKB/SwissProt
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GoogleScholar
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| CHEMBL
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PC sid
UniChem
Similars
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036554
(CHEMBL3353609)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1)C(F)(F)F)c1ncc(Cl)cc1Cl Show InChI InChI=1S/C20H13Cl2F3N2O4S/c21-15-9-17(22)18(26-10-15)27(11-12-1-5-14(6-2-12)20(23,24)25)32(30,31)16-7-3-13(4-8-16)19(28)29/h1-10H,11H2,(H,28,29) | PDB
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| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559525
(CHEMBL3934976)Show SMILES COc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
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antibodypedia
GoogleScholar
AffyNet
| KEGG
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559529
(CHEMBL3896936)Show SMILES Cc1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc1ccc(C)cc1 |r| | PDB
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TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058771
(CHEMBL3335410)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4ccccc4)CC3)cc2)cc1 Show InChI InChI=1S/C26H26F3N3O/c27-26(28,29)23-10-12-24(13-11-23)30-25(33)22-8-6-21(7-9-22)19-32-16-14-31(15-17-32)18-20-4-2-1-3-5-20/h1-13H,14-19H2,(H,30,33) | PDB
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Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058765
(CHEMBL3335416)Show SMILES C[C@@H]1CN(Cc2cccnc2)CCN1Cc1ccc(cc1)C(=O)Nc1ccc(cc1)C(F)(F)F |r| Show InChI InChI=1S/C26H27F3N4O/c1-19-16-32(17-21-3-2-12-30-15-21)13-14-33(19)18-20-4-6-22(7-5-20)25(34)31-24-10-8-23(9-11-24)26(27,28)29/h2-12,15,19H,13-14,16-18H2,1H3,(H,31,34)/t19-/m1/s1 | PDB
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Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50032651
(1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-y...)Show SMILES C[C@@H]([C@@H](O)c1ccc(O)cc1)N1CCC(O)(CC1)c1ccccc1 Show InChI InChI=1S/C20H25NO3/c1-15(19(23)16-7-9-18(22)10-8-16)21-13-11-20(24,12-14-21)17-5-3-2-4-6-17/h2-10,15,19,22-24H,11-14H2,1H3/t15-,19+/m0/s1 | PDB
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Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036541
(CHEMBL3353599)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(F)c(c1)C(F)(F)F)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C21H12ClF7N2O4S/c22-16-8-13(20(24,25)26)9-30-18(16)31(10-11-1-6-17(23)15(7-11)21(27,28)29)36(34,35)14-4-2-12(3-5-14)19(32)33/h1-9H,10H2,(H,32,33) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Endothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha
(Homo sapiens (Human)) | BDBM50058768
(CHEMBL3335413)Show SMILES FC(F)(F)c1ccc(NC(=O)c2ccc(CN3CCN(Cc4cccnc4)CC3)cc2)cc1 Show InChI InChI=1S/C25H25F3N4O/c26-25(27,28)22-7-9-23(10-8-22)30-24(33)21-5-3-19(4-6-21)17-31-12-14-32(15-13-31)18-20-2-1-11-29-16-20/h1-11,16H,12-15,17-18H2,(H,30,33) | PDB
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Eisai Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of HIF1 signaling in human U251 cells expressing VEGF by VEGF promoter-driven PLAP reporter gene assay |
Bioorg Med Chem 22: 5513-29 (2014)
Article DOI: 10.1016/j.bmc.2014.07.020
BindingDB Entry DOI: 10.7270/Q24J0GSG |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220582
(6-(2-(4-(4-fluorophenyl)-4-hydroxypiperidin-1-yl)-...)Show SMILES CC(C(O)c1ccc2NC(=O)N(C)Cc2c1)N1CCC(O)(CC1)c1ccc(F)cc1 |w:2.2,1.0| Show InChI InChI=1S/C23H28FN3O3/c1-15(21(28)16-3-8-20-17(13-16)14-26(2)22(29)25-20)27-11-9-23(30,10-12-27)18-4-6-19(24)7-5-18/h3-8,13,15,21,28,30H,9-12,14H2,1-2H3,(H,25,29) | PDB
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Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025291
(2-(3,4-Dihydroxy-phenyl)-6-hexyloxy-5,7-dimethoxy-...)Show SMILES CCCCCCOc1c(OC)cc2oc(cc(=O)c2c1OC)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C23H26O7/c1-4-5-6-7-10-29-22-20(27-2)13-19-21(23(22)28-3)17(26)12-18(30-19)14-8-9-15(24)16(25)11-14/h8-9,11-13,24-25H,4-7,10H2,1-3H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025278
(6-Butoxy-2-(3,4-dihydroxy-phenyl)-5-hydroxy-7-meth...)Show SMILES CCCCOc1c(OC)cc2oc(cc(=O)c2c1O)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C20H20O7/c1-3-4-7-26-20-17(25-2)10-16-18(19(20)24)14(23)9-15(27-16)11-5-6-12(21)13(22)8-11/h5-6,8-10,21-22,24H,3-4,7H2,1-2H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Glutamate receptor ionotropic, NMDA 2B
(Rattus norvegicus (Rat)) | BDBM50220578
(6-(2-(4-(3,4-dihydro-1H-isochromen-7-yl)-4-hydroxy...)Show SMILES CC(C(O)c1ccc2NC(=O)CCc2c1)N1CCC(O)(CC1)c1ccc2CCOCc2c1 |w:2.2,1.0| Show InChI InChI=1S/C26H32N2O4/c1-17(25(30)20-3-6-23-19(14-20)4-7-24(29)27-23)28-11-9-26(31,10-12-28)22-5-2-18-8-13-32-16-21(18)15-22/h2-3,5-6,14-15,17,25,30-31H,4,7-13,16H2,1H3,(H,27,29) | PDB
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Pfizer Global Research & Development
Curated by ChEMBL
| Assay Description
Displacement of [3H]racemic CP101606 from rat NR2B receptor in P2 membrane |
Bioorg Med Chem Lett 17: 5558-62 (2007)
Article DOI: 10.1016/j.bmcl.2007.08.014
BindingDB Entry DOI: 10.7270/Q2R21138 |
More data for this
Ligand-Target Pair | |
Transient receptor potential cation channel subfamily M member 8
(Homo sapiens (Human)) | BDBM50036551
(CHEMBL3353606)Show SMILES OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc1ccc2occc2c1)c1ncc(cc1Cl)C(F)(F)F Show InChI InChI=1S/C22H14ClF3N2O5S/c23-18-10-16(22(24,25)26)11-27-20(18)28(12-13-1-6-19-15(9-13)7-8-33-19)34(31,32)17-4-2-14(3-5-17)21(29)30/h1-11H,12H2,(H,29,30) | PDB
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RaQualia Pharma Inc.
Curated by ChEMBL
| Assay Description
Antagonist activity at human TRPM8 expressed in HEK293 cells assessed as inhibition of menthol induced Ca2+ influx |
Bioorg Med Chem Lett 24: 5364-8 (2014)
Article DOI: 10.1016/j.bmcl.2014.10.074
BindingDB Entry DOI: 10.7270/Q2TB18HX |
More data for this
Ligand-Target Pair | |
Polyunsaturated fatty acid 5-lipoxygenase
(Rattus norvegicus) | BDBM50025286
(2-(3,4-Dihydroxy-phenyl)-5-hexyloxy-6,7-dimethoxy-...)Show SMILES CCCCCCOc1c(OC)c(OC)cc2oc(cc(=O)c12)-c1ccc(O)c(O)c1 Show InChI InChI=1S/C23H26O7/c1-4-5-6-7-10-29-23-21-17(26)12-18(14-8-9-15(24)16(25)11-14)30-19(21)13-20(27-2)22(23)28-3/h8-9,11-13,24-25H,4-7,10H2,1-3H3 | PDB
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TBA
Curated by ChEMBL
| Assay Description
Ability to inhibit 5-lipoxygenase in rat basophilic leukemia cells. |
J Med Chem 29: 2256-62 (1986)
BindingDB Entry DOI: 10.7270/Q2M907P5 |
More data for this
Ligand-Target Pair | |
Sodium/glucose cotransporter 2
(Homo sapiens (Human)) | BDBM50559523
(CHEMBL3915296)Show SMILES CCCOc1ccc(Cc2c(C)[nH]nc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| | PDB
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TBA
| Assay Description
Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG uptake |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116033
BindingDB Entry DOI: 10.7270/Q29G5RHZ |
More data for this
Ligand-Target Pair | |
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