| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hypoxia-inducible factor 1-alpha |
|---|
| Ligand | BDBM50269764 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1612400 (CHEMBL3854200) |
|---|
| IC50 | 3700±n/a nM |
|---|
| Citation |  Goey, AK; Chau, CH; Sissung, TM; Cook, KM; Venzon, DJ; Castro, A; Ransom, TR; Henrich, CJ; McKee, TC; McMahon, JB; Grkovic, T; Cadelis, MM; Copp, BR; Gustafson, KR; Figg, WD Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1a/p300 Interaction. J Nat Prod79:1267-75 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hypoxia-inducible factor 1-alpha |
|---|
| Name: | Hypoxia-inducible factor 1-alpha |
|---|
| Synonyms: | BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 92647.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q16665 |
|---|
| Residue: | 826 |
|---|
| Sequence: | MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVT
VFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYR
DTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKR
KMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLAC
RLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
|
|
|
|---|
| BDBM50269764 |
|---|
| n/a |
|---|
| Name | BDBM50269764 |
|---|
| Synonyms: | (+)-Discorhabdin B | CHEMBL459120 | Discorhabdin A | discorhabdin B |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H12BrN3O2S |
|---|
| Mol. Mass. | 414.276 |
|---|
| SMILES | BrC1=C[C@]23C[C@H](SC2=CC1=O)N=C1C3C2=NCCc3c[nH]c(c23)C1=O |r,c:8,13,t:1,17| |
|---|
| Structure | 
|
|---|
Search and Browse
