| Reaction Details |
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 | Report a problem with these data |
| Target | G protein-coupled receptor kinase 5 |
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| Ligand | BDBM50191325 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1612831 (CHEMBL3854631) |
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| IC50 | 631000±n/a nM |
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| Citation |  Guccione, M; Ettari, R; Taliani, S; Da Settimo, F; Zappalą, M; Grasso, S G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitors: Current Trends and Future Perspectives. J Med Chem59:9277-9294 (2016) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| G protein-coupled receptor kinase 5 |
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| Name: | G protein-coupled receptor kinase 5 |
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| Synonyms: | G protein-coupled receptor kinase 5 | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5 | GRK5_BOVIN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 67903.06 |
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| Organism: | Bos taurus |
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| Description: | ChEMBL_116955 |
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| Residue: | 590 |
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| Sequence: | MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYCSLCDKQ
PVGRLLFRQFCETRPGLESYIQFLDSVAEYEVTPDEKLGEKGKEIMTKYLTPKSPVFITQ
VGRDLVSQTEEKLLQKPCKELFSACVQSVHDYLRGEPFHEYLDSMYFDRFLQWKWLERQP
VTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEK
VNSRFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLE
DLHHENIVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQ
RYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSIC
KMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDI
EQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQSEMIETECFKELNVFGPHGTLSPDLNRS
HPPEPPKKGLLQRLFKRQHQNNSKSSPNSKTSFNHHINSNHVSSNSTGSS
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| BDBM50191325 |
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| n/a |
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| Name | BDBM50191325 |
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| Synonyms: | CHEMBL3918278 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H19F4N5O |
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| Mol. Mass. | 493.4556 |
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| SMILES | CC1=C(C(N=C(N1)c1ccc(cc1)C(F)(F)F)c1ccc(F)cc1)C(=O)Nc1ccc2[nH]ncc2c1 |c:4,t:1| |
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| Structure | 
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