| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/hydrogen exchanger 5 |
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| Ligand | BDBM50196789 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1618881 (CHEMBL3861050) |
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| IC50 | 291±n/a nM |
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| Citation |  Rackelmann, N; Matter, H; Englert, H; Follmann, M; Maier, T; Weston, J; Arndt, P; Heyse, W; Mertsch, K; Wirth, K; Bialy, L Discovery and Optimization of 1-Phenoxy-2-aminoindanes as Potent, Selective, and Orally Bioavailable Inhibitors of the Na J Med Chem59:8812-8829 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/hydrogen exchanger 5 |
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| Name: | Sodium/hydrogen exchanger 5 |
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| Synonyms: | NHE5 | SL9A5_HUMAN | SLC9A5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 99022.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_141051 |
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| Residue: | 896 |
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| Sequence: | MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLA
KIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSG
YFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSL
ISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDY
LKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLS
AILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWD
SGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLD
RTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHI
LAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFV
DQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVM
HHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKS
KPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDE
GIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETT
KIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFA
FPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
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| BDBM50196789 |
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| n/a |
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| Name | BDBM50196789 |
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| Synonyms: | CHEMBL3892788 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H24Cl3FN4O2 |
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| Mol. Mass. | 513.82 |
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| SMILES | Cl.Cc1nnc(C)n1-c1ccc(O[C@@H]2[C@H](Cc3c2cc(Cl)cc3Cl)N2CC[C@@H](O)C2)c(F)c1 |r| |
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| Structure | 
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