| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Progesterone receptor |
|---|
| Ligand | BDBM50198655 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1620821 (CHEMBL3863104) |
|---|
| IC50 | 230±n/a nM |
|---|
| Citation |  Kinoshita, M; Negishi, M; Sakai, H; Hirano, T; Mori, S; Fujii, S; Kagechika, H; Tanatani, A Development of 6-arylcoumarins as nonsteroidal progesterone antagonists. Structure-activity relationships and fluorescence properties. Bioorg Med Chem24:5602-5610 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Progesterone receptor |
|---|
| Name: | Progesterone receptor |
|---|
| Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 98979.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P06401 |
|---|
| Residue: | 933 |
|---|
| Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
|
|
|
|---|
| BDBM50198655 |
|---|
| n/a |
|---|
| Name | BDBM50198655 |
|---|
| Synonyms: | CHEMBL3948334 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C23H18N2O3 |
|---|
| Mol. Mass. | 370.4006 |
|---|
| SMILES | COc1cc2oc(=O)cc(C)c2cc1-c1ccc(C#N)n1Cc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
