| Reaction Details |
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 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
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| Ligand | BDBM50148751 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1622696 (CHEMBL3865048) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Huang, W; Hulverson, MA; Zhang, Z; Choi, R; Hart, KJ; Kennedy, M; Vidadala, RSR; Maly, DJ; Van Voorhis, WC; Lindner, SE; Fan, E; Ojo, KK 5-Aminopyrazole-4-carboxamide analogues are selective inhibitors of Plasmodium falciparum microgametocyte exflagellation and potential malaria transmission blocking agents. Bioorg Med Chem Lett26:5487-5491 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calmodulin-domain protein kinase 1 |
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| Name: | Calmodulin-domain protein kinase 1 |
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| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50148751 |
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| n/a |
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| Name | BDBM50148751 |
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| Synonyms: | CHEMBL3769798 | US9518026, Example 72 | US9956214, Compound 1630 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25N5O2 |
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| Mol. Mass. | 379.4555 |
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| SMILES | CC(C)(C)n1nc(c(C(N)=O)c1N)-c1cnc2cc(OC3CCC3)ccc2c1 |
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| Structure | 
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