Reaction Details |
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Target | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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Ligand | BDBM50057477 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_204601 (CHEMBL813363) |
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IC50 | 4.2±n/a nM |
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Citation | Sato, H; Kitagawa, O; Aida, Y; Chikazawa, J; Kurimoto, T; Takei, M; Fukuta, Y; Yoshida, K Dual-acting agents with alpha1-adrenoceptor antagonistic and steroid 5alpha-reductase inhibitory activities. Synthesis and evaluation of arylpiperazine derivatives. Bioorg Med Chem Lett9:1553-8 (1999) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
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Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1/2 |
Synonyms: | Steroid 5-alpha-reductase |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 204723 |
Components: | This complex has 2 components. |
Component 1 |
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 |
Synonyms: | S5A1_RAT | Srd5a1 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 1 |
Type: | PROTEIN |
Mol. Mass.: | 29788.29 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_1441437 |
Residue: | 259 |
Sequence: | MVPLMELDELCLLDMLVYLEGFMAFVSIVGLRSVGSPYGRYSPQWPGIRVPARPAWFIQE
LPSMAWPLYEYIRPAAARLGNLPNRVLLAMFLIHYVQRTLVFPVLIRGGKPTLLVTFVLA
FLFCTFNGYVQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGE
TGYKIPRGGLFEYVSAANYFGELVEWCGFALASWSLQGVVFALFTLSTLLTRAKQHHQWY
HEKFEDYPKSRKILIPFVL
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Component 2 |
Name: | 3-oxo-5-alpha-steroid 4-dehydrogenase 2 |
Synonyms: | S5A2_RAT | Srd5a2 | Steroid 5-alpha-reductase | Steroid 5-alpha-reductase 2 |
Type: | PROTEIN |
Mol. Mass.: | 28784.15 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_205054 |
Residue: | 254 |
Sequence: | MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPS
FVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCI
GNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRI
PRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFK
DYPKSRKALIPFIF
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BDBM50057477 |
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n/a |
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Name | BDBM50057477 |
Synonyms: | 4-(3-{3-[(4-Isobutyl-benzyl)-(4-isobutyl-phenyl)-amino]-benzoyl}-indol-1-yl)-butyric acid | 4-[3-(3-{[Bis-(4-isobutyl-phenyl)-methyl]-amino}-benzoyl)-indol-1-yl]-butyric acid | CHEMBL25083 | FK-143 |
Type | Small organic molecule |
Emp. Form. | C40H44N2O3 |
Mol. Mass. | 600.789 |
SMILES | CC(C)Cc1ccc(cc1)C(Nc1cccc(c1)C(=O)c1cn(CCCC(O)=O)c2ccccc12)c1ccc(CC(C)C)cc1 |
Structure |
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