Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50405983 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_55072 (CHEMBL858271) |
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Ki | 2138±n/a nM |
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Citation | Hansch, C; Li, R; Blaney, JM; Langridge, R Comparison of the inhibition of Escherichia coli and Lactobacillus casei dihydrofolate reductase by 2,4-diamino-5-(substituted-benzyl)pyrimidines: quantitative structure-activity relationships, X-ray crystallography, and computer graphics in structure-activity analysis. J Med Chem25:777-84 (1982) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_LACCA | dhfR | folA |
Type: | PROTEIN |
Mol. Mass.: | 18437.08 |
Organism: | Lactobacillus casei |
Description: | ChEMBL_1357878 |
Residue: | 163 |
Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50405983 |
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n/a |
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Name | BDBM50405983 |
Synonyms: | CHEMBL32067 |
Type | Small organic molecule |
Emp. Form. | C12H14N4O |
Mol. Mass. | 230.2658 |
SMILES | Nc1ncc(Cc2cccc(CO)c2)c(N)n1 |
Structure |
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