Reaction Details |
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Target | Orexin/Hypocretin receptor type 1 |
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Ligand | BDBM50233306 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1650595 |
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IC50 | 1636±n/a nM |
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Citation | Wu, S; Sun, Y; Hu, Y; Zhang, H; Hou, L; Liu, X; Li, Y; He, H; Luo, Z; Chen, Y; Wang, Y; Shi, W; Shen, L; Cao, C; Liang, W; Xu, Q; Lv, Q; Lan, J; Li, J; Chen, S Discovery of novel substituted octahydropyrrolo[3,4-c]pyrroles as dual orexin receptor antagonists for insomnia treatment. Bioorg Med Chem Lett27:1458-1462 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Orexin/Hypocretin receptor type 1 |
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Name: | Orexin/Hypocretin receptor type 1 |
Synonyms: | HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r |
Type: | Protein |
Mol. Mass.: | 47554.50 |
Organism: | Homo sapiens (Human) |
Description: | O43613 |
Residue: | 425 |
Sequence: | MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
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BDBM50233306 |
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n/a |
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Name | BDBM50233306 |
Synonyms: | CHEMBL4093272 |
Type | Small organic molecule |
Emp. Form. | C24H25N7O |
Mol. Mass. | 427.5016 |
SMILES | [H][C@@]12CN(C[C@]1([H])CN(C2)c1nc2ccccc2n1C)C(=O)c1cc(C)ccc1-n1nccn1 |r| |
Structure |
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