| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM50234312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1652668 (CHEMBL4001923) |
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| IC50 | 3830±n/a nM |
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| Citation |  Hamdy, R; Ziedan, NI; Ali, S; Bordoni, C; El-Sadek, M; Lashin, E; Brancale, A; Jones, AT; Westwell, AD Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. Bioorg Med Chem Lett27:1037-1040 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM50234312 |
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| n/a |
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| Name | BDBM50234312 |
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| Synonyms: | CHEMBL4066452 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11N5O3 |
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| Mol. Mass. | 321.2902 |
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| SMILES | [O-][N+](=O)c1ccc(Nc2nnc(o2)-c2c[nH]c3ccccc23)cc1 |
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| Structure | 
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