| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50235590 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657492 (CHEMBL4006962) |
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| IC50 | 108±n/a nM |
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| Citation |  Sainas, S; Pippione, AC; Giorgis, M; Lupino, E; Goyal, P; Ramondetti, C; Buccinną, B; Piccinini, M; Braga, RC; Andrade, CH; Andersson, M; Moritzer, AC; Friemann, R; Mensa, S; Al-Kadaraghi, S; Boschi, D; Lolli, ML Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem129:287-302 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50235590 |
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| n/a |
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| Name | BDBM50235590 |
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| Synonyms: | CHEMBL4071260 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14F4N4O2 |
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| Mol. Mass. | 406.3337 |
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| SMILES | Oc1nn(CC2CC2)nc1C(=O)Nc1c(F)c(F)c(c(F)c1F)-c1ccccc1 |
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| Structure | 
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