Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50235595 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1657492 (CHEMBL4006962) |
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IC50 | 44±n/a nM |
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Citation | Sainas, S; Pippione, AC; Giorgis, M; Lupino, E; Goyal, P; Ramondetti, C; Buccinną, B; Piccinini, M; Braga, RC; Andrade, CH; Andersson, M; Moritzer, AC; Friemann, R; Mensa, S; Al-Kadaraghi, S; Boschi, D; Lolli, ML Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem129:287-302 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50235595 |
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n/a |
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Name | BDBM50235595 |
Synonyms: | CHEMBL4081077 |
Type | Small organic molecule |
Emp. Form. | C16H6F7N3O3S |
Mol. Mass. | 453.291 |
SMILES | Oc1nsnc1C(=O)Nc1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F |
Structure |
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