| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50235698 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657731 (CHEMBL4007201) |
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| IC50 | >27000±n/a nM |
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| Citation |  Zaware, N; Kisliuk, R; Bastian, A; Ihnat, MA; Gangjee, A Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett27:1602-1607 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50235698 |
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| n/a |
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| Name | BDBM50235698 |
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| Synonyms: | CHEMBL4069070 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H17N5O2S |
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| Mol. Mass. | 367.425 |
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| SMILES | COc1ccc(OC)c(Sc2cccc3[nH]c4nc(N)nc(N)c4c23)c1 |
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| Structure | 
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