| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50235696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657731 (CHEMBL4007201) |
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| IC50 | >28000±n/a nM |
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| Citation |  Zaware, N; Kisliuk, R; Bastian, A; Ihnat, MA; Gangjee, A Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett27:1602-1607 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21453.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHFR. |
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| Residue: | 187 |
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| Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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| BDBM50235696 |
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| n/a |
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| Name | BDBM50235696 |
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| Synonyms: | CHEMBL4060383 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N5S |
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| Mol. Mass. | 357.432 |
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| SMILES | Nc1nc(N)c2c(n1)[nH]c1cccc(Sc3ccc4ccccc4c3)c21 |
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| Structure | 
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