Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50235697 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1657731 (CHEMBL4007201) |
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IC50 | >27000±n/a nM |
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Citation | Zaware, N; Kisliuk, R; Bastian, A; Ihnat, MA; Gangjee, A Synthesis and evaluation of 5-(arylthio)-9H-pyrimido[4,5-b]indole-2,4-diamines as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents. Bioorg Med Chem Lett27:1602-1607 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50235697 |
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n/a |
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Name | BDBM50235697 |
Synonyms: | CHEMBL4088617 |
Type | Small organic molecule |
Emp. Form. | C20H15N5S |
Mol. Mass. | 357.432 |
SMILES | Nc1nc(N)c2c(n1)[nH]c1cccc(Sc3cccc4ccccc34)c21 |
Structure |
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