| Reaction Details |
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 | Report a problem with these data |
| Target | Indoleamine 2,3-dioxygenase 1 |
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| Ligand | BDBM58106 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658250 (CHEMBL4007862) |
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| IC50 | 3300±n/a nM |
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| Citation |  Tomek, P; Palmer, BD; Flanagan, JU; Sun, C; Raven, EL; Ching, LM Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions. Eur J Med Chem126:983-996 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Indoleamine 2,3-dioxygenase 1 |
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| Name: | Indoleamine 2,3-dioxygenase 1 |
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| Synonyms: | I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 45330.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P14902 |
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| Residue: | 403 |
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| Sequence: | MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVE
KLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLEL
PPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKV
IPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGN
PQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMP
PAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQ
QPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
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| BDBM58106 |
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| n/a |
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| Name | BDBM58106 |
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| Synonyms: | 6-(1,3-dihydrophenanthr[9,10-d]imidazol-2-ylidene)cyclohexa-2,4-dien-1-one | 6-(1,3-dihydrophenanthro[9,10-d]imidazol-2-ylidene)-1-cyclohexa-2,4-dienone | 6-(1,3-dihydrophenanthro[9,10-d]imidazol-2-ylidene)cyclohexa-2,4-dien-1-one | MLS000758520 | SMR000528957 | cid_5384447 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H14N2O |
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| Mol. Mass. | 310.3487 |
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| SMILES | Oc1ccccc1-c1nc2c([nH]1)c1ccccc1c1ccccc21 |
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| Structure | 
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