| Reaction Details |
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 | Report a problem with these data |
| Target | dCTP pyrophosphatase 1 |
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| Ligand | BDBM38321 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1658761 (CHEMBL4008373) |
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| IC50 | 19±n/a nM |
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| Citation |  Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem60:2148-2154 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| dCTP pyrophosphatase 1 |
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| Name: | dCTP pyrophosphatase 1 |
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| Synonyms: | DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1) |
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| Type: | Protein |
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| Mol. Mass.: | 18673.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9H773 |
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| Residue: | 170 |
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| Sequence: | MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLAL
VGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLS
KMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
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| BDBM38321 |
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| n/a |
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| Name | BDBM38321 |
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| Synonyms: | 6-(3,4-dimethoxyphenyl)-3-(2-furanyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-(2-furyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | MLS000037114 | SMR000042111 | cid_661498 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N4O3S |
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| Mol. Mass. | 328.346 |
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| SMILES | COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1ccco1 |
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| Structure | 
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