Reaction Details |
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Target | Nicotinamide phosphoribosyltransferase |
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Ligand | BDBM50236217 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1658849 (CHEMBL4008461) |
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IC50 | 3.1±n/a nM |
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Citation | Travelli, C; Aprile, S; Rahimian, R; Grolla, AA; Rogati, F; Bertolotti, M; Malagnino, F; di Paola, R; Impellizzeri, D; Fusco, R; Mercalli, V; Massarotti, A; Stortini, G; Terrazzino, S; Del Grosso, E; Fakhfouri, G; Troiani, MP; Alisi, MA; Grosa, G; Sorba, G; Canonico, PL; Orsomando, G; Cuzzocrea, S; Genazzani, AA; Galli, U; Tron, GC Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity. J Med Chem60:1768-1792 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nicotinamide phosphoribosyltransferase |
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Name: | Nicotinamide phosphoribosyltransferase |
Synonyms: | NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1 |
Type: | PROTEIN |
Mol. Mass.: | 55450.71 |
Organism: | Mus musculus |
Description: | ChEMBL_108315 |
Residue: | 491 |
Sequence: | MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVP
EGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNA
QLNIEQDVAPH
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BDBM50236217 |
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n/a |
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Name | BDBM50236217 |
Synonyms: | CHEMBL4061448 |
Type | Small organic molecule |
Emp. Form. | C27H29N5O |
Mol. Mass. | 439.5521 |
SMILES | O=C(NCCCCCCCn1cc(nn1)-c1cccnc1)c1ccccc1-c1ccccc1 |
Structure |
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