| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Nicotinamide phosphoribosyltransferase |
|---|
| Ligand | BDBM81395 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1658849 (CHEMBL4008461) |
|---|
| IC50 | 4.9±n/a nM |
|---|
| Citation |  Travelli, C; Aprile, S; Rahimian, R; Grolla, AA; Rogati, F; Bertolotti, M; Malagnino, F; di Paola, R; Impellizzeri, D; Fusco, R; Mercalli, V; Massarotti, A; Stortini, G; Terrazzino, S; Del Grosso, E; Fakhfouri, G; Troiani, MP; Alisi, MA; Grosa, G; Sorba, G; Canonico, PL; Orsomando, G; Cuzzocrea, S; Genazzani, AA; Galli, U; Tron, GC Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity. J Med Chem60:1768-1792 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Nicotinamide phosphoribosyltransferase |
|---|
| Name: | Nicotinamide phosphoribosyltransferase |
|---|
| Synonyms: | NAMPT_MOUSE | NAmPRTase | Nampt | Pbef1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55450.71 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_108315 |
|---|
| Residue: | 491 |
|---|
| Sequence: | MNAAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKVRKVKYEETVFY
GLQYILNKYLKGKVVTKEKIQEAKEVYREHFQDDVFNERGWNYILEKYDGHLPIEVKAVP
EGSVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETS
GNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGIALIKKYYGTKDPVPGY
SVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIV
SRSTEAPLIIRPDSGNPLDTVLKVLDILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINT
LQEIVEGMKQKKWSIENVSFGSGGALLQKLTRDLLNCSFKCSYVVTNGLGVNVFKDPVAD
PNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGHDLLHTVFKNGKVTKSYSFDEVRKNA
QLNIEQDVAPH
|
|
|
|---|
| BDBM81395 |
|---|
| n/a |
|---|
| Name | BDBM81395 |
|---|
| Synonyms: | APO-866 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H29N3O2 |
|---|
| Mol. Mass. | 391.506 |
|---|
| SMILES | O=C(NCCCCC1CCN(CC1)C(=O)c1ccccc1)\C=C\c1cccnc1 |
|---|
| Structure | 
|
|---|
Search and Browse
