| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1B |
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| Ligand | BDBM143282 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Assay |
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| IC50 | 38.0±n/a nM |
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| Citation |  Alimardanov, A; Cuny, GD; Grewal, GS; Lee, A; McKew, JC; Mohedas, AH; Shen, M; Xu, X; Yu, PB BMP inhibitors and methods of use thereof US Patent US10017516 Publication Date 7/10/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1B |
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| Name: | Bone morphogenetic protein receptor type-1B |
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| Synonyms: | ALK-6 | ALK6 | BMPR1B | BMR1B_HUMAN | Bone morphogenetic protein receptor type-1B (BMPR1B) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56939.41 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O00238 |
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| Residue: | 502 |
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| Sequence: | MLLRSAGKLNVGTKKEDGESTAPTPRPKVLRCKCHHHCPEDSVNNICSTDGYCFTMIEED
DSGLPVVTSGCLGLEGSDFQCRDTPIPHQRRSIECCTERNECNKDLHPTLPPLKNRDFVD
GPIHHRALLISVTVCSLLLVLIILFCYFRYKRQETRPRYSIGLEQDETYIPPGESLRDLI
EQSQSSGSGSGLPLLVQRTIAKQIQMVKQIGKGRYGEVWMGKWRGEKVAVKVFFTTEEAS
WFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDYLKSTTLDAKS
MLKLAYSSVSGLCHLHTEIFSTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISD
TNEVDIPPNTRVGTKRYMPPEVLDESLNRNHFQSYIMADMYSFGLILWEVARRCVSGGIV
EEYQLPYHDLVPSDPSYEDMREIVCIKKLRPSFPNRWSSDECLRQMGKLMTECWAHNPAS
RLTALRVKKTLAKMSESQDIKL
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| BDBM143282 |
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| n/a |
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| Name | BDBM143282 |
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| Synonyms: | US10017516, Compound 10 | US9682983, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N6 |
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| Mol. Mass. | 420.509 |
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| SMILES | Cc1cc(-c2cnn3cc(cnc23)-c2ccc(cc2)N2CCNCC2)c2ccccc2n1 |
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| Structure | 
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