| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bifunctional protein GlmU |
|---|
| Ligand | BDBM92474 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.35±0 |
|---|
| IC50 | >2.00e+5±n/a nM |
|---|
| Citation |  Buurman, ET; Andrews, B; Gao, N; Hu, J; Keating, TA; Lahiri, S; Otterbein, LR; Patten, AD; Stokes, SS; Shapiro, AB In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae. J Biol Chem286:40734-42 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Bifunctional protein GlmU |
|---|
| Name: | Bifunctional protein GlmU |
|---|
| Synonyms: | Bifunctional protein (GlmU) | GLMU_STAAC | Glucosamine-1-phosphate N-acetyltransferase | UDP-N-acetylglucosamine pyrophosphorylase | gcaD | glmU |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48525.06 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | Q5HIH6 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MRRHAIILAAGKGTRMKSKKYKVLHEVAGKPMVEHVLESVKGSGVDQVVTIVGHGAESVK
GHLGERSLYSFQEEQLGTAHAVQMAKSHLEDKEGTTIVVCGDTPLITKETLETLIAHHED
ANAQATVLSASIQQPYGYGRIVRNASGRLERIVEEKDATQAEKDINEISSGIFAFNNKTL
FEKLTQVKNDNAQGEYYLPDVLSLILNDGGIVEVYRTNDVEEIMGVNDRVMLSQAEKAMQ
RRTNHYHMLNGVTIIDPDSTYIGPDVTIGSDTVIEPGVRINGRTEIGEDVVIGQYSEINN
STIENGACIQQSVVNDASVGANTKVGPFAQLRPGAQLGADVKVGNFVEIKKADLKDGAKV
SHLSYIGDAVIGERTNIGCGTITVNYDGENKFKTIVGKDSFVGCNVNLVAPVTIGDDVLV
AAGSTITDDVPNDSLAVARARQTTKEGYRK
|
|
|
|---|
| BDBM92474 |
|---|
| n/a |
|---|
| Name | BDBM92474 |
|---|
| Synonyms: | Sulfonamide, 5 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H22N2O8S |
|---|
| Mol. Mass. | 498.505 |
|---|
| SMILES | COc1cc(OC)c(cc1NC(=O)CCC(O)=O)S(=O)(=O)N1c2ccccc2Oc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
