| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM92604 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Continuous Assay |
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| IC50 | 4.2e+2± 2e+1 nM |
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| Citation |  Patel, V; Booker, M; Kramer, M; Ross, L; Celatka, CA; Kennedy, LM; Dvorin, JD; Duraisingh, MT; Sliz, P; Wirth, DF; Clardy, J Identification and characterization of small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem283:35078-85 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial, putative |
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| Type: | PROTEIN |
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| Mol. Mass.: | 62972.27 |
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| Organism: | Plasmodium vivax |
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| Description: | A5K1N1 |
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| Residue: | 572 |
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| Sequence: | MLRHSCLREKGNLIGGSLLRGISAQLRAAGGGTFRSFHSYRSFCSFCIFRRANKADANWY
GCFPGHVAGGATCGPLRGDCAERHKLMAHVRRFSGESTRAKGGDKREGDIEGNRTNGSDK
TKQLEEEMKKLNEQIAREKGNHKKALLFIFTCVVALYMYFESYDPEFFLYDVFLKMLLKY
VDGETCHELFLLMGKYKLLPYDTGKDNIYSCSEIKGLNFINPFGVAAGFDKNGVCIDGIL
KLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGCDEVCKNLKRFRERQK
TDKLLQRHLVGVSLGKNKDSPDILQDLSYCIGKIGRYADYIAINVSSPNTPGLRDHQKGE
RLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVVGKAPPDEAATGGEPWAN
TTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTTQKFNIKSFEDKKGGVSG
EKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIEAGASVCQLYSCLVFNGMKA
AVRIKRELDHLLYQRGYYKLGDAVGRAHRRAA
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| BDBM92604 |
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| n/a |
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| Name | BDBM92604 |
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| Synonyms: | DHOD Inhibitor, 3 | US8703811, 1 |
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| Type | Small molecule |
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| Emp. Form. | C17H18N2OS |
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| Mol. Mass. | 298.403 |
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| SMILES | CCCNC(=O)c1ccc(s1)-n1c(C)cc2ccccc12 |
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| Structure | 
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