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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12972 ((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12973 ((2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12974 ((2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12962 ((2S)-2-({[1-(4-bromophenyl)ethyl]carbamoyl}amino)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12968 ((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12977 ((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12970 ((2S)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12975 ((2S)-2-[(2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carb...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12976 ((2S)-2-({[(1R)-1-(4-bromophenyl)ethyl]carbamoyl}am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | KEGG PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120351 (US8703811, 93) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120317 (US8703811, 58) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120319 (US8703811, 60) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium vivax) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Assay was determined using a continuous assay. | J Biol Chem 283: 35078-85 (2008) Article DOI: 10.1074/jbc.M804990200 BindingDB Entry DOI: 10.7270/Q2VH5MFQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120301 (US8703811, 40 | US8703811, 41) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium vivax) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120323 (US8703811, 64) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120324 (US8703811, 65) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM92604 (DHOD Inhibitor, 3 | US8703811, 1) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12963 ((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120315 (US8703811, 55) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120305 (US8703811, 44) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM50379142 (CHEMBL2012824 | US8703811, 23) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120301 (US8703811, 40 | US8703811, 41) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120328 (US8703811, 70) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Assay was determined using a continuous assay. | J Biol Chem 283: 35078-85 (2008) Article DOI: 10.1074/jbc.M804990200 BindingDB Entry DOI: 10.7270/Q2VH5MFQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92604 (DHOD Inhibitor, 3 | US8703811, 1) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Assay was determined using a continuous assay. | J Biol Chem 283: 35078-85 (2008) Article DOI: 10.1074/jbc.M804990200 BindingDB Entry DOI: 10.7270/Q2VH5MFQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92604 (DHOD Inhibitor, 3 | US8703811, 1) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12955 ((2S)-N-[(1S)-1-{[(2S)-5-carbamimidamido-1-oxo-1-(1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM92604 (DHOD Inhibitor, 3 | US8703811, 1) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM50379157 (CHEMBL1234899 | US8703811, 57) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | MMDB PDB US Patent | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120325 (US8703811, 66) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM92604 (DHOD Inhibitor, 3 | US8703811, 1) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM50379146 (CHEMBL2012829 | US8703811, 31 | US8703811, 32) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120320 (US8703811, 61) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12956 ((2S,3R)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 76 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Assay was determined using a continuous assay. | J Biol Chem 283: 35078-85 (2008) Article DOI: 10.1074/jbc.M804990200 BindingDB Entry DOI: 10.7270/Q2VH5MFQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM92606 (DHOD Inhibitor, 5 | US8703811, 6) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120303 (US8703811, 42 | US8703811, 43) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 88 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120356 (US8703811, 98) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Coagulation factor XI (Homo sapiens (Human)) | BDBM12946 ((2S)-N-[(2S)-5-carbamimidamido-1-oxo-1-(1,3-thiazo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 93 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Daiichi Asubio Medical Research Laboratories LLC (DAIAMED) | Assay Description Enzyme peptidolytic activities were measured using a fluorogenic reporter group, 7-amido-4-methylcoumarin (AMC). Released AMC was measured at an emis... | J Med Chem 49: 7781-91 (2006) Article DOI: 10.1021/jm060978s BindingDB Entry DOI: 10.7270/Q2SJ1HTM | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120312 (US8703811, 52) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM50379146 (CHEMBL2012829 | US8703811, 31 | US8703811, 32) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50379157 (CHEMBL1234899 | US8703811, 57) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysis | ACS Med Chem Lett 2: 708-713 (2011) Article DOI: 10.1021/ml200143c BindingDB Entry DOI: 10.7270/Q2C24XDS | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120303 (US8703811, 42 | US8703811, 43) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 104 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120326 (US8703811, 68) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120353 (US8703811, 95) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92603 (DHOD Inhibitor, 2 | US8703811, 3) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial [100-517] (Plasmodium berghei) | BDBM92603 (DHOD Inhibitor, 2 | US8703811, 3) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Harvard Medical School | Assay Description Assay was determined using a continuous assay. | J Biol Chem 283: 35078-85 (2008) Article DOI: 10.1074/jbc.M804990200 BindingDB Entry DOI: 10.7270/Q2VH5MFQ | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Dihydroorotate dehydrogenase (quinone), mitochondrial (Plasmodium falciparum) | BDBM120321 (US8703811, 62) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 112 | n/a | n/a | n/a | n/a | n/a | n/a |
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College US Patent | Assay Description Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al... | US Patent US8703811 (2014) BindingDB Entry DOI: 10.7270/Q2WD3Z7P | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
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