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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ||
| Ligand | BDBM99055 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Inhibition Assay | ||
| IC50 | 15.75±n/a nM | ||
| Citation |  Allen, JR; Horne, DB; Harrington, EH; Kaller, MR; Monenschein, H; Nguyen, TT; Reichelt, A; Rzasa, RM Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors US Patent US8497265 Publication Date 7/30/2013 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | |||
| Name: | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | ||
| Synonyms: | PDE10_RAT | Pde10a | Phosphodiesterase 10 | Phosphodiesterase 10A (PDE10A2) | Phosphodiesterase Type 10 (PDE10A) | Rat recombinant PDE10a (rPDE10a) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 90160.88 | ||
| Organism: | Rattus norvegicus (rat) | ||
| Description: | PDE10A was generated from the full-length recombinant rat clone transfected into Sf9 cells. | ||
| Residue: | 794 | ||
| Sequence: |
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| BDBM99055 | |||
| n/a | |||
| Name | BDBM99055 | ||
| Synonyms: | US8497265, 739 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H28N2O4 | ||
| Mol. Mass. | 348.4366 | ||
| SMILES | CC(C)(C)OC(=O)N1CC(C1)Oc1ncccc1[C@H]1CC[C@H](O)CC1 |r,wU:18.19,wD:21.23,(6.28,-2.85,;4.94,-3.62,;4.94,-5.16,;6.28,-4.39,;3.61,-2.85,;2.28,-3.62,;2.28,-5.16,;.94,-2.85,;-.54,-3.25,;-.94,-1.77,;.54,-1.37,;-2.28,-1,;-3.61,-1.77,;-3.61,-3.31,;-4.94,-4.08,;-6.28,-3.31,;-6.28,-1.77,;-4.94,-1,;-4.94,.54,;-6.28,1.31,;-6.28,2.85,;-4.94,3.62,;-4.94,5.16,;-3.61,2.85,;-3.61,1.31,)| | ||
| Structure | 
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