Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Mitogen-activated protein kinase 8 | ||
Ligand | BDBM102573 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Inhibition Assay | ||
pH | 7.5±0 | ||
IC50 | 3.6±n/a nM | ||
Citation | Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Mitogen-activated protein kinase 8 | |||
Name: | Mitogen-activated protein kinase 8 | ||
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 48297.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
Residue: | 427 | ||
Sequence: |
| ||
BDBM102573 | |||
n/a | |||
Name | BDBM102573 | ||
Synonyms: | US8536172, I-22 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H42N8O5S | ||
Mol. Mass. | 626.77 | ||
SMILES | CC(C)(C)OC(=O)NCC(=O)N1CCN(CC1)c1cccc2n(ccc12)-c1ccnc(N[C@H]2CC[C@@H](CC2)NS(C)(=O)=O)n1 |r,wU:32.34,wD:35.41,(10.7,-6.58,;9.21,-6.18,;8.12,-7.27,;9.61,-4.7,;8.81,-4.7,;7.32,-4.3,;6.24,-5.39,;6.93,-2.81,;5.44,-2.41,;5.04,-.92,;6.13,.17,;3.55,-.53,;2.46,-1.61,;.98,-1.22,;.58,.27,;1.67,1.36,;3.15,.96,;-.91,.67,;-2.06,-.36,;-3.52,.12,;-3.84,1.62,;-2.7,2.65,;-2.7,4.19,;-1.23,4.67,;-.33,3.42,;-1.23,2.18,;-4.03,4.96,;-4.03,6.5,;-5.36,7.27,;-6.7,6.5,;-6.7,4.96,;-8.03,4.19,;-8.03,2.65,;-6.7,1.88,;-6.7,.34,;-8.03,-.43,;-9.36,.34,;-9.36,1.88,;-8.03,-1.97,;-9.36,-2.74,;-10.7,-1.97,;-9.36,-4.28,;-8.03,-3.51,;-5.36,4.19,)| | ||
Structure |