Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Mitogen-activated protein kinase 8 | ||
Ligand | BDBM102571 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | In Vitro Inhibition Assay | ||
pH | 7.5±0 | ||
IC50 | 40.1±n/a nM | ||
Citation | Gong, L; Han, X; Makra, F; Palmer, WS; Raptova, L Inhibitors of JNK US Patent US8536172 Publication Date 9/17/2013 | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Mitogen-activated protein kinase 8 | |||
Name: | Mitogen-activated protein kinase 8 | ||
Synonyms: | JNK-46 | JNK1 | JNK1-alpha-1 | MAPK8 | MK08_HUMAN | Mitogen-Activated Protein Kinase 8 (JNK1) | PRKM8 | SAPK1 | SAPK1C | Stress-activated protein kinase JNK1 | c-Jun N-terminal kinase 1 | c-Jun N-terminal kinase 1 (JNK1) | c-Jun N-terminal kinase 1(JNK1) | c-Jun N-terminal kinase 2 (JNK2) | ||
Type: | Enzyme | ||
Mol. Mass.: | 48297.57 | ||
Organism: | Homo sapiens (Human) | ||
Description: | JNK-1 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology). | ||
Residue: | 427 | ||
Sequence: |
| ||
BDBM102571 | |||
n/a | |||
Name | BDBM102571 | ||
Synonyms: | US8536172, I-20 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H35N5O4S | ||
Mol. Mass. | 525.663 | ||
SMILES | CCOC(=O)[C@H]1CC[C@@H](CC1)Nc1nccc(n1)-n1ccc2c(cccc12)N1CCC(CC1)S(C)(=O)=O |r,wU:8.11,wD:5.4,(-2.41,-5.01,;-3.75,-4.24,;-5.08,-5.01,;-6.41,-4.24,;-7.75,-5.01,;-6.41,-2.7,;-5.08,-1.93,;-5.08,-.39,;-6.41,.38,;-7.75,-.39,;-7.75,-1.93,;-6.41,1.92,;-5.08,2.69,;-5.08,4.23,;-3.75,5.01,;-2.41,4.23,;-2.41,2.69,;-3.75,1.92,;-1.08,1.92,;.39,2.4,;1.29,1.15,;.39,-.09,;.71,-1.6,;-.44,-2.63,;-1.9,-2.15,;-2.22,-.65,;-1.08,.38,;2.19,-2,;2.59,-3.48,;4.08,-3.88,;5.17,-2.79,;4.77,-1.31,;3.28,-.91,;6.66,-3.19,;5.57,-4.28,;7.75,-2.1,;7.06,-4.68,)| | ||
Structure |