Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM104444 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 0.91±0.0 nM |
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Citation | Guzzo, PR; Henderson, AJ; Nacro, K; Isherwood, ML; Ghosh, A; Xiang, K Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof US Patent US8575186 Publication Date 11/5/2013 |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM104444 |
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n/a |
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Name | BDBM104444 |
Synonyms: | US8575186, 207/208 | US8575186, 224 |
Type | Small organic molecule |
Emp. Form. | C20H19ClN2O3S |
Mol. Mass. | 402.894 |
SMILES | Cn1c2CC3CCC(N3)c2c2cc(cc(O)c12)S(=O)(=O)c1cccc(Cl)c1 |THB:10:9:8:6.5,1:2:8:6.5| |
Structure |
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