Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM104321 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Binding Assay |
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Ki | 0.42±0.0 nM |
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Citation | Guzzo, PR; Henderson, AJ; Nacro, K; Isherwood, ML; Ghosh, A; Xiang, K Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof US Patent US8575186 Publication Date 11/5/2013 |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM104321 |
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n/a |
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Name | BDBM104321 |
Synonyms: | US8575186, 250 | US8575186, 251 | US8575186, 84/234/235 |
Type | Small organic molecule |
Emp. Form. | C22H24N2O3S |
Mol. Mass. | 396.503 |
SMILES | CCOc1cc(cc2c3C4CCC(Cc3n(C)c12)N4)S(=O)(=O)c1ccccc1 |THB:7:8:18:10.11,15:14:18:10.11| |
Structure |
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