| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
|---|
| Ligand | BDBM281767 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | PDK1 kinase assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Arndt, J; Chan, T; Guckian, K; Kumaravel, G; Lee, W; Lin, EY; Scott, D; Sun, L; Thomas, J; van Vloten, K; Wang, D; Zhang, L; Erlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 3-phosphoinositide-dependent protein kinase 1 [51-359] |
|---|
| Name: | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
|---|
| Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | PDK1 | PDK1 (aa 51-359) | PDPK1 | PDPK1_HUMAN | hPDK1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 35302.26 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O15530[51-359] |
|---|
| Residue: | 309 |
|---|
| Sequence: | MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
|
|
|
|---|
| BDBM281767 |
|---|
| n/a |
|---|
| Name | BDBM281767 |
|---|
| Synonyms: | 2-(3-(1H-pyrrolo[2,3-b]pyridin- 3-yl)benzylamino)-N-(4- fluorobenzyl)nicotinamide | US10030016, Example 1.6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H22FN5O |
|---|
| Mol. Mass. | 451.4949 |
|---|
| SMILES | Fc1ccc(CNC(=O)c2cccnc2NCc2cccc(c2)-c2c[nH]c3ncccc23)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
