Reaction Details |
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Target | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
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Ligand | BDBM282439 |
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Substrate/Competitor | n/a |
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Meas. Tech. | PDK1 kinase assay |
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IC50 | <100±n/a nM |
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Citation | Arndt, J; Chan, T; Guckian, K; Kumaravel, G; Lee, W; Lin, EY; Scott, D; Sun, L; Thomas, J; van Vloten, K; Wang, D; Zhang, L; Erlanson, D Heterocyclic compounds useful as PDK1 inhibitors US Patent US10030016 Publication Date 7/24/2018 |
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More Info.: | Get all data from this article, Assay Method |
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3-phosphoinositide-dependent protein kinase 1 [51-359] |
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Name: | 3-phosphoinositide-dependent protein kinase 1 [51-359] |
Synonyms: | 3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) | 3-phosphoinositide-dependent protein kinase 1 | 3-phosphoinositide-dependent protein kinase 1 (aa 51-359) | PDK1 | PDK1 (aa 51-359) | PDPK1 | PDPK1_HUMAN | hPDK1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 35302.26 |
Organism: | Homo sapiens (Human) |
Description: | O15530[51-359] |
Residue: | 309 |
Sequence: | MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
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BDBM282439 |
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n/a |
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Name | BDBM282439 |
Synonyms: | (S)-3-(4-(4-amino-7- (2-aminoethyl)- 7H-pyrrolo[2,3-d] pyrimidin-5-yl) benzylamino)-6- cyano-N-(1-(3,4-difluoro- phenyl)ethyl)pyrazine-2- carboxamide | US10030016, Example 319 |
Type | Small organic molecule |
Emp. Form. | C29H26F2N10O |
Mol. Mass. | 568.5799 |
SMILES | C[C@H](NC(=O)c1nc(cnc1NCc1ccc(cc1)-c1cn(CCN)c2ncnc(N)c12)C#N)c1ccc(F)c(F)c1 |r| |
Structure |
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