Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM116318 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | JAK1 and TYK2 Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 28.7±n/a nM | ||
| Comments | extracted | ||
| Citation |  Blaney, J; Gibbons, PA; Hanan, E; Lyssikatos, JP; Magnuson, SR; Pastor, R; Rawson, TE; Zhou, A; Zhu, B Pyrazolopyrimidine JAK inhibitor compounds and methods US Patent US8637526 Publication Date 1/28/2014 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM116318 | |||
| n/a | |||
| Name | BDBM116318 | ||
| Synonyms: | US8637526, 299 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H25N5O2 | ||
| Mol. Mass. | 391.4662 | ||
| SMILES | O[C@H]1CCC(CC1)NC(=O)c1cnn2ccc(NC3CCc4ccccc34)nc12 |r,wU:1.0,(-2.56,-5.93,;-2.16,-4.44,;-3.25,-3.35,;-2.85,-1.87,;-1.36,-1.47,;-.27,-2.56,;-.67,-4.04,;-.96,.02,;-2.05,1.11,;-3.54,.71,;-1.66,2.6,;-2.56,3.84,;-1.66,5.09,;-.19,4.61,;1.14,5.38,;2.48,4.61,;2.48,3.07,;3.81,2.3,;3.81,.76,;2.56,-.14,;3.04,-1.61,;4.58,-1.61,;5.67,-2.7,;7.16,-2.3,;7.56,-.81,;6.47,.28,;5.06,-.14,;1.14,2.3,;-.19,3.07,)| | ||
| Structure | 
| ||