Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM118171

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

3.8±n/a nM

Comments

extracted

Citation

Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent US8653125 Publication Date 2/18/2014

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

52807.91

Organism:

Mus musculus (Mouse)

Description:

O70342

Residue:

466

Sequence:

MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDD
LQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTL
TSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFL
IATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQ
YILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSY
SFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVK
PEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISN
RHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS

BDBM118171

n/a

Name

BDBM118171

Synonyms:

US8653125, Ia-4

Type

Small organic molecule

Emp. Form.

C22H21ClFN5O2

Mol. Mass.

441.886

SMILES

Fc1ccccc1-n1ccc(NC(=O)[C@@H]2CC[C@@H](CC2)NC(=O)c2cccc(Cl)n2)n1 |r,wU:17.21,14.14,(7.08,-.52,;7.85,-1.85,;9.39,-1.85,;10.16,-3.18,;9.39,-4.52,;7.85,-4.52,;7.08,-3.18,;5.54,-3.18,;4.64,-4.43,;3.17,-3.95,;3.17,-2.41,;1.84,-1.64,;.51,-2.41,;.51,-3.95,;-.83,-1.64,;-.83,-.1,;-2.16,.67,;-3.49,-.1,;-3.49,-1.64,;-2.16,-2.41,;-4.83,.67,;-6.16,-.1,;-6.16,-1.64,;-7.5,.67,;-8.83,-.1,;-10.16,.67,;-10.16,2.21,;-8.83,2.98,;-8.83,4.52,;-7.5,2.21,;4.64,-1.94,)|

Structure