Ki Summary

Reaction Details

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Target

Neuropeptide Y receptor type 5

Ligand

BDBM118188

Substrate/Competitor

n/a

Meas. Tech.

Binding Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

0.56±n/a nM

Comments

extracted

Citation

Yoshida, H; Tonogaki, K; Sakagami, M; Takaya, K Cyclohexane derivative having NPY Y5 receptor antagonism US Patent US8653125 Publication Date 2/18/2014

More Info.:

Get all data from this article, Assay Method

Neuropeptide Y receptor type 5

Name:

Neuropeptide Y receptor type 5

Synonyms:

Type:

Enzyme

Mol. Mass.:

52807.91

Organism:

Mus musculus (Mouse)

Description:

O70342

Residue:

466

Sequence:

MEVKLEEHFNKTFVTENNTAASQNTASPAWEDYRGTENNTSAARNTAFPVWEDYRGSVDD
LQYFLIGLYTFVSLLGFMGNLLILMAVMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTL
TSVLLDQWMFGKAMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFL
IATVWTLGFAICSPLPVFHSLVELKETFGSALLSSKYLCVESWPSDSYRIAFTISLLLVQ
YILPLVCLTVSHTSVCRSISCGLSHKENRLEENEMINLTLHPSKKSRDQAKPPSTQKWSY
SFIRKHRRRYSKKTACVLPAPAGPSQEKHLTVPENPGSVRSQLSPSSKVIPGVPICFEVK
PEESSDAQEMRVKRSLTRIKKRSRSVFYRLTILILVFAVSWMPLHVFHVVTDFNDNLISN
RHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLRALIHCLHMS

BDBM118188

n/a

Name

BDBM118188

Synonyms:

US8653125, Ic-13

Type

Small organic molecule

Emp. Form.

C24H24ClN3O4

Mol. Mass.

453.918

SMILES

CC(C)n1c2ccc(NC(=O)[C@@H]3CC[C@@H](CC3)Oc3cc(Cl)ccc3C#N)cc2oc1=O |r,wU:14.17,11.10,(6.15,-5.38,;7.24,-4.29,;8.73,-4.69,;6.84,-2.8,;5.38,-2.32,;4.05,-3.09,;2.71,-2.32,;2.71,-.78,;1.38,-.01,;.05,-.78,;.05,-2.32,;-1.29,-.01,;-1.29,1.53,;-2.62,2.3,;-3.96,1.53,;-3.96,-.01,;-2.62,-.78,;-5.29,2.3,;-6.62,1.53,;-6.62,-.01,;-7.96,-.78,;-7.96,-2.32,;-9.29,-.01,;-9.29,1.53,;-7.96,2.3,;-7.96,3.84,;-7.96,5.38,;4.05,-.01,;5.38,-.78,;6.84,-.31,;7.75,-1.55,;9.29,-1.55,)|

Structure